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Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells
Our understanding of Alzheimer’s disease pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model the sporadic form of the disease. It mayExpand
Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer's Disease
We identified axonal defects in mouse models of Alzheimer's disease that preceded known disease-related pathology by more than a year; we observed similar axonal defects in the early stages ofExpand
Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice
The most common form of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting adult motor neurons, is caused by dominant mutations in the ubiquitously expressed Cu-Zn superoxideExpand
Somatic coding mutations in human induced pluripotent stem cells
Defined transcription factors can induce epigenetic reprogramming of adult mammalian cells into induced pluripotent stem cells. Although DNA factors are integrated during some reprogramming methods,Expand
The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation.
Yes-associated protein (YAP) is a potent transcription coactivator acting via binding to the TEAD transcription factor, and plays a critical role in organ size regulation. YAP is phosphorylated andExpand
Axonal Transport of Amyloid Precursor Protein Is Mediated by Direct Binding to the Kinesin Light Chain Subunit of Kinesin-I
We analyzed the mechanism of axonal transport of the amyloid precursor protein (APP), which plays a major role in the development of Alzheimer's disease. Coimmunoprecipitation, sucrose gradient, andExpand
JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins.
Microtubules (MTs) play an important role in elaboration and maintenance of axonal and dendritic processes. MT dynamics are modulated by MT-associated proteins (MAPs), whose activities are regulatedExpand
CENP-E Is a Plus End–Directed Kinetochore Motor Required for Metaphase Chromosome Alignment
Mitosis requires dynamic attachment of chromosomes to spindle microtubules. This interaction is mediated largely by kinetochores. During prometaphase, forces exerted at kinetochores, in combinationExpand
Kinesin-Dependent Axonal Transport Is Mediated by the Sunday Driver (SYD) Protein
A broadly conserved membrane-associated protein required for the functional interaction of kinesin-I with axonal cargo was identified. Mutations in sunday driver (syd) and the axonal transport motorExpand
Anastral meiotic spindle morphogenesis: role of the non-claret disjunctional kinesin-like protein
We have used time-lapse laser scanning confocal microscopy to directly examine microtubule reorganization during meiotic spindle assembly in living Drosophila oocytes. These studies indicate that theExpand