Hyperphosphorylation of Tau in PHF

@article{Morishimakawashima1995HyperphosphorylationOT,
  title={Hyperphosphorylation of Tau in PHF},
  author={M. Morishima-kawashima and M. Hasegawa and K. Takio and Masami Suzuki and Y. Ihara},
  journal={Neurobiology of Aging},
  year={1995},
  volume={16},
  pages={365-371}
}
Tau in PHF is known to be highly phosphorylated and immunochemical study has indicated the similarity of the phosphorylation between PHF-tau and fetal tau. We have determined the exact phosphorylation sites in both PHF-tau and fetal rat tau by ion-spray mass spectrometry and sequencing of ethanethiol-modified peptides. In PHF-tau, 19 sites have been identified; all the phosphorylation sites except for Ser-262 are localized to the amino- and carboxyl-terminal flanking regions of the microtubule… Expand
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