negative regulation of sprouting angiogenesis
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During sprouting angiogenesis, an individual endothelial tip cell grows out from a pre-existing vascular network and guides… Expand Hypoxia is a main driver of sprouting angiogenesis, but how tip endothelial cells are directed to hypoxic regions remains poorly… Expand Endothelial cell migration, proliferation and survival are triggered by VEGF-A activation of VEGFR2. However, how these cell… Expand Pericytes are mural cells that surround capillaries and control angiogenesis and capillary barrier function. During sprouting… Expand The term angiogenesis arose in the 18th century. Several studies over the next 100 years laid the groundwork for initial studies… Expand Sprouting angiogenesis, where new blood vessels grow from pre-existing ones, is a complex process where biochemical and… Expand Sprouting angiogenesis consists of the expansion and remodelling of existing vessels, where the vascular sprouts connect each… Expand During angiogenesis, endothelial tip cells start sprouting and express delta-like 4 (DLL4) downstream of vascular endothelial… Expand Sprouting angiogenesis requires a coordinated guidance from a variety of angiogenic factors. Here, we have developed a unique… Expand In sprouting angiogenesis, specialized endothelial tip cells lead the outgrowth of blood-vessel sprouts towards gradients of… Expand