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A molecular network for de novo generation of the apical surface and lumen
TLDR
This research finds that Rab11a regulates apical traffic and lumen formation through the Rab guanine nucleotide exchange factor (GEF), Rabin8, and its target, Rab8a, and reveals an interaction between the machineries of vesicular transport and polarization. Expand
PTEN-Mediated Apical Segregation of Phosphoinositides Controls Epithelial Morphogenesis through Cdc42
TLDR
It is concluded that the mechanism of PTEN, PtdIns(4,5)P2, Anx2, Cdc42, and aPKC controls apical plasma membrane and lumen formation. Expand
Receptor-mediated transcytosis of IgA in MDCK cells is via apical recycling endosomes
TLDR
A model in whichTranscytosis is not a specialized pathway that uses unique transcytotic vesicles, but rather combines portions of pathways used by non-transcytosing molecules is proposed. Expand
From cells to organs: building polarized tissue
TLDR
This work discusses how conserved polarity complexes, signalling networks, transcription factors, membrane-trafficking pathways, mechanisms for forming lumens in tubes and other hollow structures, and transitions between different types of polarity, such as between epithelial and mesenchymal cells, are used in similar and iterative manners to build all tissues. Expand
Building epithelial architecture: insights from three-dimensional culture models
TLDR
It is proposed that the morphogenetic behaviour of epithelial cells is guided by two distinct elements: an intrinsic differentiation programme that drives formation of a lumen-enclosing monolayer, and a growth factor-induced, transient de-differentiation that allows this monolayers to be remodelled. Expand
The Polymeric Immunoglobulin Receptor Translocates Pneumococci across Human Nasopharyngeal Epithelial Cells
TLDR
The results suggest that pneumococci are a novel example of a pathogen co-opting the pIg transcytosis machinery to promote translocation across a mucosal barrier. Expand
An Fc receptor structurally related to MHC class I antigens
TLDR
A cDNA encoding the presumptive Fc-binding subunit, p51, has been cloned and its predicted primary structure has three extracellular domains and a transmembrane region which are all homologous to the corresponding domains of class I major histocompatibility complex (MHC) antigens. Expand
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma.
TLDR
Surprisingly, a single agent (PI-103) effected proliferative arrest in glioma cells, despite the ability of many compounds to block PI3 kinase signaling through its downstream effector, Akt. Expand
Beta1-integrin orients epithelial polarity via Rac1 and laminin.
TLDR
A signaling pathway in which the activation of beta1-integrins orients the apical pole of polarized cysts via a mechanism that requires Rac1 activation and laminin organization into the basement membrane is suggested. Expand
Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly
TLDR
It is reported that orientation of apical polarity in developing Madin–Darby canine kidney (MDCK) epithelial cysts requires the small GTPase Rac1 and the basement membrane component laminin and Rac1-mediated laminIn assembly in apical pole orientation. Expand
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