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A molecular network for de novo generation of the apical surface and lumen
- David M. Bryant, A. Datta, Alejo E. Rodriguez-Fraticelli, J. Peränen, F. Martín-Belmonte, K. Mostov
- BiologyNature Cell Biology
- 1 November 2010
This research finds that Rab11a regulates apical traffic and lumen formation through the Rab guanine nucleotide exchange factor (GEF), Rabin8, and its target, Rab8a, and reveals an interaction between the machineries of vesicular transport and polarization.
PTEN-Mediated Apical Segregation of Phosphoinositides Controls Epithelial Morphogenesis through Cdc42
Receptor-mediated transcytosis of IgA in MDCK cells is via apical recycling endosomes
A model in whichTranscytosis is not a specialized pathway that uses unique transcytotic vesicles, but rather combines portions of pathways used by non-transcytosing molecules is proposed.
From cells to organs: building polarized tissue
This work discusses how conserved polarity complexes, signalling networks, transcription factors, membrane-trafficking pathways, mechanisms for forming lumens in tubes and other hollow structures, and transitions between different types of polarity, such as between epithelial and mesenchymal cells, are used in similar and iterative manners to build all tissues.
Guidelines and definitions for research on epithelial–mesenchymal transition
This Consensus Statement is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications to reduce misunderstanding and misinterpretation of research data generated in various experimental models.
Building epithelial architecture: insights from three-dimensional culture models
It is proposed that the morphogenetic behaviour of epithelial cells is guided by two distinct elements: an intrinsic differentiation programme that drives formation of a lumen-enclosing monolayer, and a growth factor-induced, transient de-differentiation that allows this monolayers to be remodelled.
The Polymeric Immunoglobulin Receptor Translocates Pneumococci across Human Nasopharyngeal Epithelial Cells
Faculty Opinions recommendation of Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta.
- K. Mostov
- 28 October 2001
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma.
An Fc receptor structurally related to MHC class I antigens
A cDNA encoding the presumptive Fc-binding subunit, p51, has been cloned and its predicted primary structure has three extracellular domains and a transmembrane region which are all homologous to the corresponding domains of class I major histocompatibility complex (MHC) antigens.