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negative regulation of RNA interference

Known as: down-regulation of RNAi, negative regulation of RNAi, inhibition of posttranscriptional gene silencing by siRNA 
Any process that stops, prevents or reduces the frequency, rate or extent of RNA interference. [GOC:kmv, GOC:TermGenie, PMID:22412382]
National Institutes of Health

Related topics

Related topics

2 relations
RNA Interference

Broader (1)

biological control

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
A simplified method for manufacturing RNAi therapeutics for local administration.
2019
2019
Insights into the effect of molecular crowding on the structure, interactions and functions of siRNA–PAZ complex through molecular dynamics studies
Abstract siRNA molecules are well known to be involved in the post-transcriptional regulation of gene expression and play a key… 
2017
2017
Preparation of a Microporous Polyurethane Film with Negative Surface Charge for siRNA Delivery via Stent
Polyurethane (PU) and polyethylene glycol (PEG) were used to prepare a porous stent-covering material for the controlled delivery… 
2017
2017
Oxime Ether Lipids as Transfection Agents: Assembly and Complexation with siRNA.
RNAi-based therapeutic approaches to combat cancer and other diseases are currently an area of great interest. However, practical… 
2014
2014
The delivery and evaluation of RNAi therapeutics for heterotopic ossification pathologies.
RNA interference (RNAi) is a powerful tool being used to develop therapies for pathologies caused by gene overexpression… 
2014
2014
Novel siRNA delivery system using a ternary polymer complex with strong silencing effect and no cytotoxicity.
We developed a novel small interfering RNA (siRNA) delivery system using a ternary complex with polyethyleneimine (PEI) and… 
Review
2012
Review
2012
Critical issues in delivery of RNAi therapeutics in vivo.
RNA interference (RNAi) is a fundamental mechanism of gene regulation and has been harnessed to produce a new class of drugs for… 
2012
2012
Mucosal Delivery of RNAi Therapeutics
The effectiveness of RNA interference-based drugs is dependent on accumulation at the target site in therapeutically relevant… 
2011
2011
Removable nanocoatings for siRNA polyplexes.
To assist in overcoming the inherent instability of nucleic acid-containing polyplexes in physiological solutions, we have here… 
2009
2009
RNAi using a chitosan/siRNA nanoparticle system: in vitro and in vivo applications.
Delivery is a key issue in development of clinically relevant RNAi therapeutics. Polymeric nanoparticles formed by self-assembly… 
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