negative regulation of RNA interference

Known as: down-regulation of RNAi, negative regulation of RNAi, inhibition of posttranscriptional gene silencing by siRNA 
Any process that stops, prevents or reduces the frequency, rate or extent of RNA interference. [GOC:kmv, GOC:TermGenie, PMID:22412382]
National Institutes of Health

Related topics

Related topics

2 relations
RNA Interference

Broader (1)

biological control

Papers overview

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2015
2015
Localized RNAi therapeutics of chemoresistant grade IV glioma using hyaluronan-grafted lipid-based nanoparticles.
Glioblastoma multiforme (GBM) is one of the most infiltrating, aggressive, and poorly treated brain tumors. Progress in genomics… (More)
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2015
2015
Antineoplastic Effects of siRNA against TMPRSS2-ERG Junction Oncogene in Prostate Cancer
TMPRSS2-ERG junction oncogene is present in more than 50% of patients with prostate cancer and its expression is frequently… (More)
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2014
2014
Enhanced silencing and stabilization of siRNA polyplexes by histidine-mediated hydrogen bonds.
Branched peptides containing histidines and lysines (HK) have been shown to be effective carriers for DNA and siRNA. We… (More)
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2012
2012
FRET-labeled siRNA probes for tracking assembly and disassembly of siRNA nanocomplexes.
The assembly, stability, and timely disassembly of short interfering RNA (siRNA) nanocomplexes have the potential to affect the… (More)
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2011
2011
Self-assembled siRNA-PLGA conjugate micelles for gene silencing.
Biodegradable poly(D,L-lactic-co-glycolic acid) (PLGA) was conjugated to the 3' end of small interfering RNA (siRNA) via a… (More)
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Highly Cited
2010
Highly Cited
2010
Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms.
Lipid nanoparticles (LNPs) have proven to be highly efficient carriers of short-interfering RNAs (siRNAs) to hepatocytes in vivo… (More)
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Highly Cited
2010
Highly Cited
2010
Identification of MIR390a precursor processing-defective mutants in Arabidopsis by direct genome sequencing.
Transacting siRNA (tasiRNA) biogenesis in Arabidopsis is initiated by microRNA (miRNA) -guided cleavage of primary transcripts… (More)
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Highly Cited
2008
Highly Cited
2008
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
The safe and effective delivery of RNA interference (RNAi) therapeutics remains an important challenge for clinical development… (More)
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Review
2008
Review
2008
The business of RNAi therapeutics.
BUSINESS FOR RNA INTERFERENCE (RNAi) therapeutics has never been better. The confluence of the genome revolution, a… (More)
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Highly Cited
2006
Highly Cited
2006
Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly(ethylene imine)-graft-poly(ethylene glycol) block copolymer/SiRNA polyplexes.
Polyplexes between siRNA and poly(ethylene imine) (PEI) derivatives are promising nonviral carriers for siRNA. The polyplex… (More)
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