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negative regulation of RNA interference

Known as: down-regulation of RNAi, negative regulation of RNAi, inhibition of posttranscriptional gene silencing by siRNA 
Any process that stops, prevents or reduces the frequency, rate or extent of RNA interference. [GOC:kmv, GOC:TermGenie, PMID:22412382]
National Institutes of Health

Related topics

Related topics

2 relations
RNA Interference

Broader (1)

biological control

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Co-delivery of HIF1α siRNA and gemcitabine via biocompatible lipid-polymer hybrid nanoparticles for effective treatment of pancreatic cancer.
Highly Cited
2015
Highly Cited
2015
Localized RNAi therapeutics of chemoresistant grade IV glioma using hyaluronan-grafted lipid-based nanoparticles.
Glioblastoma multiforme (GBM) is one of the most infiltrating, aggressive, and poorly treated brain tumors. Progress in genomics… 
Highly Cited
2014
Highly Cited
2014
Enhanced silencing and stabilization of siRNA polyplexes by histidine-mediated hydrogen bonds.
Review
2013
Review
2013
Nanoparticle-Based Delivery of RNAi Therapeutics: Progress and Challenges
RNA interference (RNAi) is an evolutionarily conserved, endogenous process for post-transcriptional regulation of gene expression… 
Review
2012
Review
2012
Therapeutic plasmid DNA versus siRNA delivery: common and different tasks for synthetic carriers.
Highly Cited
2011
Highly Cited
2011
Self-assembled siRNA-PLGA conjugate micelles for gene silencing.
Highly Cited
2010
Highly Cited
2010
Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms.
Lipid nanoparticles (LNPs) have proven to be highly efficient carriers of short-interfering RNAs (siRNAs) to hepatocytes in vivo… 
Highly Cited
2010
Highly Cited
2010
Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms.
Lipid nanoparticles (LNPs) have proven to be highly efficient carriers of short-interfering RNAs (siRNAs) to hepatocytes in vivo… 
Highly Cited
2009
Highly Cited
2009
Identification of MIR390a precursor processing-defective mutants in Arabidopsis by direct genome sequencing
Transacting siRNA (tasiRNA) biogenesis in Arabidopsis is initiated by microRNA (miRNA) –guided cleavage of primary transcripts… 
Highly Cited
2006
Highly Cited
2006
Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly(ethylene imine)-graft-poly(ethylene glycol) block copolymer/SiRNA polyplexes.
Polyplexes between siRNA and poly(ethylene imine) (PEI) derivatives are promising nonviral carriers for siRNA. The polyplex… 
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