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negative regulation of RNA interference
Known as:
down-regulation of RNAi
, negative regulation of RNAi
, inhibition of posttranscriptional gene silencing by siRNA
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Any process that stops, prevents or reduces the frequency, rate or extent of RNA interference. [GOC:kmv, GOC:TermGenie, PMID:22412382]
National Institutes of Health
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Related topics
Related topics
2 relations
RNA Interference
Broader (1)
biological control
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
A simplified method for manufacturing RNAi therapeutics for local administration.
Hidenori Ando
,
A. S. Abu Lila
,
+7 authors
T. Ishida
International journal of pharmaceutics
2019
Corpus ID: 129941889
2019
2019
Insights into the effect of molecular crowding on the structure, interactions and functions of siRNA–PAZ complex through molecular dynamics studies
R. Anand
,
B. Sanjeev
Journal of Biomolecular Structure and Dynamics
2019
Corpus ID: 51715796
Abstract siRNA molecules are well known to be involved in the post-transcriptional regulation of gene expression and play a key…
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2017
2017
Preparation of a Microporous Polyurethane Film with Negative Surface Charge for siRNA Delivery via Stent
Il-Hoon Cho
,
Sangsoo Park
2017
Corpus ID: 55554117
Polyurethane (PU) and polyethylene glycol (PEG) were used to prepare a porous stent-covering material for the controlled delivery…
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2017
2017
Oxime Ether Lipids as Transfection Agents: Assembly and Complexation with siRNA.
A. Puri
,
Serena Zampino
,
Mathias Viard
,
B. Shapiro
Methods in molecular biology
2017
Corpus ID: 4818123
RNAi-based therapeutic approaches to combat cancer and other diseases are currently an area of great interest. However, practical…
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2014
2014
The delivery and evaluation of RNAi therapeutics for heterotopic ossification pathologies.
Arun R. Shrivats
,
J. Hollinger
Methods in molecular biology
2014
Corpus ID: 27644616
RNA interference (RNAi) is a powerful tool being used to develop therapies for pathologies caused by gene overexpression…
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2014
2014
Novel siRNA delivery system using a ternary polymer complex with strong silencing effect and no cytotoxicity.
Yukinobu Kodama
,
Yumi Shiokawa
,
+7 authors
H. Sasaki
Biological and Pharmaceutical Bulletin
2014
Corpus ID: 13147323
We developed a novel small interfering RNA (siRNA) delivery system using a ternary complex with polyethyleneimine (PEI) and…
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Review
2012
Review
2012
Critical issues in delivery of RNAi therapeutics in vivo.
S. Rivera
,
F. Yuan
Current Pharmaceutical Biotechnology
2012
Corpus ID: 37419726
RNA interference (RNAi) is a fundamental mechanism of gene regulation and has been harnessed to produce a new class of drugs for…
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2012
2012
Mucosal Delivery of RNAi Therapeutics
Borja Ballarín González
,
E. Nielsen
,
T. Thomsen
,
K. Howard
RNA Interference from Biology to Therapeutics
2012
Corpus ID: 74344529
The effectiveness of RNA interference-based drugs is dependent on accumulation at the target site in therapeutically relevant…
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2011
2011
Removable nanocoatings for siRNA polyplexes.
L. Kostka
,
Č. Koňák
,
+5 authors
K. Ulbrich
Bioconjugate chemistry
2011
Corpus ID: 45224102
To assist in overcoming the inherent instability of nucleic acid-containing polyplexes in physiological solutions, we have here…
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2009
2009
RNAi using a chitosan/siRNA nanoparticle system: in vitro and in vivo applications.
M. Andersen
,
K. Howard
,
J. Kjems
Methods in molecular biology
2009
Corpus ID: 24209285
Delivery is a key issue in development of clinically relevant RNAi therapeutics. Polymeric nanoparticles formed by self-assembly…
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