T. Ishida

Publications254
h-index49
Citations8,645
Highly Influential Citations192
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Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes.
Liposome Clearance
TLDR
The role of serum proteins, so-called opsonins, that enhance the clearance of liposome clearance, when bound to liposomes, is focused on.
Spleen plays an important role in the induction of accelerated blood clearance of PEGylated liposomes.
Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes.
Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes.
Targeted delivery and triggered release of liposomal doxorubicin enhances cytotoxicity against human B lymphoma cells.
Accelerated blood clearance of PEGylated liposomes upon repeated injections: effect of doxorubicin-encapsulation and high-dose first injection.
Accelerated blood clearance of PEGylated liposomes following preceding liposome injection: effects of lipid dose and PEG surface-density and chain length of the first-dose liposomes.
A combinatorial approach to producing sterically stabilized (Stealth) immunoliposomal drugs
PEGylated liposomes: immunological responses
TLDR
This review presents PEGylated liposomes, immunogenicity of PEG, the ABC phenomenon, C activation and lipid-induced CARPA from a toxicological point of view, and also addresses the factors that influence these adverse interactions with the immune system.
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