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naxagolide

Known as: 4-propyl-9-hydroxy-1,2,3,4a,5,6-hexahydronaphthoxazine, 4-propyl-9-hydroxynaphthoxazine, (+)-4-propyl-9-hydroxynaphthoxazine 
National Institutes of Health

Related topics

Related topics

5 relations

Narrower (2)

11C-PHNON 0500

Broader (3)

Antiparkinson AgentsDopamine AgonistsOxazines

Papers overview

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2019
2019
The Dopamine D2 Receptor Contributes to the Spheroid Formation Behavior of U87 Glioblastoma Cells
Background: Glioblastoma multiforme (GBM) is a common and lethal cancer of the central nervous system. This cancer is difficult… 
2010
2010
Neuroprotection and Functional Recovery Associated with Decreased Microglial Activation Following Selective Activation of mGluR2/3 Receptors in a Rodent Model of Parkinson's Disease
Clinical trials have demonstrated positive proof of efficacy of dual metabotropic glutamate receptor 2/3 (mGluR2/3) agonists in… 
Highly Cited
1996
Highly Cited
1996
Differential effects of direct and indirect dopamine agonists on eye blink rate in cynomolgus monkeys.
Spontaneous eye blink rate was assessed in cynomolgus monkeys treated intramuscularly with the high-efficacy dopamine (DA… 
Highly Cited
1994
Highly Cited
1994
Comparison between the pharmacology of dopamine receptors mediating the inhibition of cell firing in rat brain slices through the substantia nigra pars compacta and ventral tegmental area
1 Electrophysiological recordings were made from presumed dopaminergic neurones in the substantia nigra pars compacta and ventral… 
1993
1993
Relative potency and efficacy of some dopamine agonists with varying selectivities for D1 and D2 receptors in MPTP-induced hemiparkinsonian monkeys.
A series of dopamine agonists were studied on contraversive circling behavior in seven 1-methyl-4-phenyl-1,2,3,6… 
1991
1991
Enantiomers of monohydroxy-2-aminotetralin derivatives and their activity at dopamine autoreceptors as studied by brain dialysis.
1990
1990
Metabolism of antiparkinson agent dopazinol by rat liver microsomes.
Metabolism of dopazinol (DZ) by liver microsomes from control and phenobarbital- and 3-methylcholanthrene-treated rats has been… 
1988
1988
A sensitive gas chromatographic mass spectrometric assay for a novel dopamine agonist (+)-trans-3,4,4A,5,6,10B-hexahydro-4-propyl-2H-naphth(1,2-B)(1,4) oxazin-9-ol in human plasma.
(+)-trans-3,4,4A,5,6,10B-Hexahydro-4-propyl-2H-naphth(1,2-B)(1,4) oxazine-9-ol is a novel potent dopamine agonist. A sensitive… 
1985
1985
Selectivity of (+)-4-propyl-9-hydroxynaphthoxazine [(+)-PHNO] for dopamine receptors in vitro and in vivo.
The intrinsic activity of the potent dopamine (DA) agonist 4-propyl-9-hydroxynaphthoxazine [(+)-PHNO] was examined in receptor… 
Highly Cited
1984
Highly Cited
1984
Pharmacologic profile of a novel potent direct-acting dopamine agonist, (+)-4-propyl-9-hydroxynaphthoxazine [(+)-PHNO].
The (+)-enantiomer of 1,2,3,4a,5,6-hexahydro-9-hydroxy-4-n-propyl-4H-naphth[1,2-b][ 1,4]-oxazine [(+)-PHNO] is demonstrated to be… 
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