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Behavioural and neurochemical studies on apomorphine-induced hypomotility in mice
TLDR
It appears that yohimbine may inhibit apomorphine-induced hypomotility by acting at α 2 -adrenergic receptors and that, in addition to dopaminergic receptors, nor adrenergic systems may be involved in apomorphin-induced Hypomotive response. Expand
The effect of systemically applied cholinergic drugs on the striatal release of dopamine and its metabolites, as determined by automated brain dialysis in conscious rats
TLDR
The most interesting findings of the present study are the fact that muscarinic receptor stimulation or blockade does not modify the release of DA from the rat striatum, while nicotine receptor stimulation may exert some stimulatory effect on therelease of DA. Expand
Abstracts of papers
s of Papers Presented at the 2nd European Conference on Social Media ECSM 2015 School of Accounting and Administration at the Polytechnic Institute of Porto Portugal
Catecholamine uptake by synaptosomes from rat brain. Structure-activity relationships of drugs with differential effects on dopamine and norepinephrine neurons.
A number of centrally active drugs, including antiparkinsonian agents, antihistamines, tricyclic antidepressants, and phenothiazines, inhibit catecholamine uptake into synaptosomes prepared fromExpand
STRUCTURE ACTIVITY RELATIONS FOR THE INHIBITION OF 5‐HT UPTAKE INTO RAT HYPOTHALAMIC HOMOGENATES BY SEROTONIN AND TRYPTAMINE ANALOGUES
  • A. Horn
  • Chemistry, Medicine
  • Journal of neurochemistry
  • 1 October 1973
TLDR
Various 5‐HT and tryptamine analogues have been examined as inhibitors of [3H]5‐HT uptake into rat hypothalamic homogenates and several of the compounds tested are known to be either hallucinogens or antidepressants. Expand
The Action of Neuroleptic Drugs on Dopamine-Stimulated Adenosine Cyclic 3',5'-Monophosphate Production in Rat Neostriatum and Limbic Forebrain
Neuroleptic drugs of various types were more potent inhibitors of dopamine-sensitive production of adenosine cyclic 39,59-monophosphate in homogenates of rat brain striatum than non-neuroleptic drugsExpand
Biochemical evidence for the 5-HT agonist properties of PAT (8-hydroxy-2-(di-n-propylamino)tetralin) in the rat brain.
TLDR
It is concluded that PAT is a potent 5-HT agonist acting on both post- and presynaptic 5- HT receptors in the rat brain. Expand
The effect of acetylcholinesterase inhibition on the release of acetylcholine from the striatum in vivo: Interaction with autoreceptor responses
TLDR
This study shows that the addition of 0.1 microM neostigmine bromide to the perfusion Ringer in a dialysis experiment attenuates the responses obtained by infusion of 100 microM oxotremorine and potentiates the effect of infusion of 1 microM atropine. Expand
A COMPARISON OF THE FACILITATORY ACTIONS OF 4‐AMINOPYRI‐DINE METHIODIDE AND 4‐AMINOPYRIDINE ON NEUROMUSCULAR TRANSMISSION
TLDR
It is concluded that 4‐APMI increases evoked acetylcholine release and also possesses a weak anticholinesterase action in homogenates of chick biventer cervicis muscle. Expand
Pharmacological profiles of three new, potent and selective dopamine receptor agonists: N-0434, N-0437 and N-0734.
TLDR
All three compounds are potent and selective DA agonists that lack significant alpha 2 activity and N-0437 seems to be a most promising candidate for further evaluation for possible therapeutic use. Expand
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