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Behavioural and neurochemical studies on apomorphine-induced hypomotility in mice
The Action of Neuroleptic Drugs on Dopamine-Stimulated Adenosine Cyclic 3',5'-Monophosphate Production in Rat Neostriatum and Limbic Forebrain
Neuroleptic drugs of various types were more potent inhibitors of dopamine-sensitive production of adenosine cyclic 39,59-monophosphate in homogenates of rat brain striatum than non-neuroleptic drugs…
The effect of systemically applied cholinergic drugs on the striatal release of dopamine and its metabolites, as determined by automated brain dialysis in conscious rats
Abstracts of papers
s of Papers Presented at the 2nd European Conference on Social Media ECSM 2015 School of Accounting and Administration at the Polytechnic Institute of Porto Portugal
Catecholamine uptake by synaptosomes from rat brain. Structure-activity relationships of drugs with differential effects on dopamine and norepinephrine neurons.
A number of centrally active drugs, including antiparkinsonian agents, antihistamines, tricyclic antidepressants, and phenothiazines, inhibit catecholamine uptake into synaptosomes prepared from…
STRUCTURE ACTIVITY RELATIONS FOR THE INHIBITION OF 5‐HT UPTAKE INTO RAT HYPOTHALAMIC HOMOGENATES BY SEROTONIN AND TRYPTAMINE ANALOGUES
- A. Horn
- Chemistry, BiologyJournal of neurochemistry
- 1 October 1973
Various 5‐HT and tryptamine analogues have been examined as inhibitors of [3H]5‐HT uptake into rat hypothalamic homogenates and several of the compounds tested are known to be either hallucinogens or antidepressants.
Biochemical evidence for the 5-HT agonist properties of PAT (8-hydroxy-2-(di-n-propylamino)tetralin) in the rat brain.
Effects of dopamine-like drugs on rat striatal adenyl cyclase have implications for CNS dopamine receptor topography
The dopamine-sensitive adenyl cyclase of the rat striatum is studied in order to define some of the structural requirements for dopamine receptor agonists and it seems that these systems represent valid models of CNS dopamine receptors.
Chlorpromazine and dopamine: conformational similarities that correlate with the antischizophrenic activity of phenothiazine drugs.
- A. Horn, S. Snyder
- Chemistry, PsychologyProceedings of the National Academy of Sciences…
- 1 October 1971
The ability of phenothiazine drugs to mimic the dopamine-like conformation correlates with their antischizophrenic efficacy and the importance of a substituent in ring a, a three-carbon side chain bearing the amino group, and a hetero atom between rings a and c is explained.