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nanaomycin A

Known as: (1S,3R)-3,4,5,10-Tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3-acetic Acid, NANAFROCIN 
A quinone antibiotic isolated from Streptomyces rosa var. notoensis with activity against gram-positive bacteria, mycoplasmas and fungi. Within an… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
DNA methyltransferases (DNMTs) are involved in epigenetic regulation of the genome and are promising targets for therapeutic… Expand
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2009
2009
A series of pyranonaphthoquinone derivatives related to the known topoisomerase II inhibitor eleutherin 1 have been shown to act… Expand
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2009
2009
Tuberculosis is the leading cause of death due to a single infectious agent in the world and the emergence of multidrug-resistant… Expand
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Highly Cited
1987
Highly Cited
1987
Deoxyfrenolicin and nanaomycin A have been synthesized. Key steps in the synthesis include a phthalide annulation reaction to… Expand
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1981
1981
The enzyme reactions from NNM-A to NNM-E and from NNM-E to NNM-B were established in a cell-free system containing an extract… Expand
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1981
1981
Nanaomycin D reductase, catalyzing the conversion of nanaomycin D to nanaomycin A, which is the first step in the biosynthetic… Expand
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1980
1980
The biosynthetic relationship of the nanaomycins produced by Streptomyces rosa var. notoensis OS-3966 was studied by means of a… Expand
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1980
1980
The mode of action of nanaomycin A on Gram-positive such as Staphylococcus aureaus, Bacillus cereus and Streptococcus faecalis… Expand
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1979
1979
A new component, nanaomycin E, has been isolated from the culture broth of Streptomyces rosa var, notoensis, which had been found… Expand
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1975
1975
A new component, nanaomycin C, has been isolated from culture medium of Streptomyces rosa var. notoensis, which had been found to… Expand
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