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nanaomycin A

Known as: (1S,3R)-3,4,5,10-Tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3-acetic Acid, NANAFROCIN 
A quinone antibiotic isolated from Streptomyces rosa var. notoensis with activity against gram-positive bacteria, mycoplasmas and fungi. Within an… Expand
National Institutes of Health

Related topics

Related topics

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Broader (1)

Naphthoquinones

Papers overview

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Highly Cited
2011
Highly Cited
2011
Molecular dynamics simulations of human DNA methyltransferase 3B with selective inhibitor nanaomycin A.
DNA methyltransferases (DNMTs) are involved in epigenetic regulation of the genome and are promising targets for therapeutic… Expand
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2009
2009
Pyranonaphthoquinone derivatives of eleutherin, ventiloquinone L, thysanone and nanaomycin A possessing a diverse topoisomerase II inhibition and cytotoxicity spectrum.
A series of pyranonaphthoquinone derivatives related to the known topoisomerase II inhibitor eleutherin 1 have been shown to act… Expand
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2009
2009
Polymyxin B identified as an inhibitor of alternative NADH dehydrogenase and malate: quinone oxidoreductase from the Gram-positive bacterium Mycobacterium smegmatis.
Tuberculosis is the leading cause of death due to a single infectious agent in the world and the emergence of multidrug-resistant… Expand
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Highly Cited
1987
Highly Cited
1987
Synthesis of deoxyfrenolicin and nanaomycin A
Deoxyfrenolicin and nanaomycin A have been synthesized. Key steps in the synthesis include a phthalide annulation reaction to… Expand
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1981
1981
Biosynthesis of nanaomycin: syntheses of nanaomycin E from nanaomycin A and of nanaomycin B from nanaomycin E in a cell-free system.
The enzyme reactions from NNM-A to NNM-E and from NNM-E to NNM-B were established in a cell-free system containing an extract… Expand
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1981
1981
Biosynthesis of nanaomycin. II. Purification and properties of nanaomycin D reductase involved in the formation of nanaomycin A from nanaomycin D1.
Nanaomycin D reductase, catalyzing the conversion of nanaomycin D to nanaomycin A, which is the first step in the biosynthetic… Expand
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1980
1980
Bioconversion and biosynthesis of nanaomycins using cerulenin, a specific inhibitor of fatty acid and polyketide biosyntheses.
The biosynthetic relationship of the nanaomycins produced by Streptomyces rosa var. notoensis OS-3966 was studied by means of a… Expand
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1980
1980
The mode of action of nanaomycin A in Gram-positive bacteria.
The mode of action of nanaomycin A on Gram-positive such as Staphylococcus aureaus, Bacillus cereus and Streptococcus faecalis… Expand
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1979
1979
Structure of nanaomycin E, a new nanaomycin.
A new component, nanaomycin E, has been isolated from the culture broth of Streptomyces rosa var, notoensis, which had been found… Expand
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1975
1975
Nanaomycins, new antibiotics produced by a strain of Streptomyces. III. A new component, nanaomycin C, and biological activities of nanaomycin derivatives.
A new component, nanaomycin C, has been isolated from culture medium of Streptomyces rosa var. notoensis, which had been found to… Expand
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