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Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase)
- H. Miyadera, K. Shiomi, S. Ōmura
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 6 January 2003
Atpenins potently and specifically inhibit the succinate-ubiquinone reductase activity of mitochondrial complex II, suggesting that atpenins may be useful tools for clarifying the biochemical and structural properties ofcomplex II, as well as for determining its physiological roles in mammalian tissues.
In vitro and in vivo antimalarial activities of a non-glycosidic 18-membered macrolide antibiotic, borrelidin, against drug-resistant strains of Plasmodia.
The antimalarial profile of borrelidin is reported here, a known nonglycosidic 18-membered macrolide antibiotic with a cyclopentanecarboxylic acid side chain, in comparison with those of clinically used antimalaria drugs.
A new alkaloid AM-2282 OF Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization.
The producing strain, AM-2282 was classified as a new species and the name, Streptomyces staurosporeus AWAYA, TAKAHASHI and OMURA, nov. is proposed to show antimicrobial activity against fungi and yeast.
Five new Simplicillium species (Cordycipitaceae) from soils in Tokyo, Japan
Materials for the fungus flora of Japan (47)
Albophoma yamanashiensis isolated from a forest soil in Yamanashi Prefecture is described as a new genus belonging to Nectrioidaceae, Coelomycetes.
Macrosphelide, a novel inhibitor of cell-cell adhesion molecule. I. Taxonomy, fermentation, isolation and biological activities.
Potent anti-adherent activity was detected in fermentation extracts of microbial strain FO-5050. Active compounds designated macrosphelide A and B were isolated and the structure was determined to be…
Neoxaline, a new alkaloid produced by Aspergillus japonicus. Production, isolation and properties.
- A. Hirano, Y. Iwai, R. Masuma, K. Tei, S. Ōmura
- Chemistry, BiologyThe Journal of antibiotics
- 1 August 1979
A new alkaloid named neoxaline has been isolated from culture broth of Aspergillus japonicug Fg-551 by solvent extraction and silica gel chromatography. The compound does not possess antimicrobial…
Funalenone, a novel collagenase inhibitor produced by Aspergillus niger.
- J. Inokoshi, K. Shiomi, R. Masuma, H. Tanaka, H. Yamada, S. Ōmura
- Biology, ChemistryThe Journal of antibiotics
- 25 December 1999
Funalenone, a phenalene compound that inhibits type I collagenase (MMP-1), was isolated from mycelium of Aspergillus niger FO-5904 by solvent extaction, ODS column chromatography, Sephadex LH-20…
Penicillium viticola, a new species isolated from a grape in Japan
A new monoverticillate Penicillium species (subgenus Aspergilloides Dierckx) was isolated from a grape cultivated in Yamanashi Prefecture, Japan and is characterized by the production of slightly roughened conidia, slightly rouGhened stipes, and rapid growth on 25% glycerol nitrate agar (G25N).
Spirohexalines, new inhibitors of bacterial undecaprenyl pyrophosphate synthase, produced by Penicillium brasilianum FKI-3368
An enzyme assay for bacterial undecaprenyl pyrophosphate (UPP) synthase was performed to screen microbial culture broths for inhibitors of UPP synthase, and a new compound-designated spirohexaline was isolated together with the structurally related and known viridicatumtoxin.