K. Otoguro

Publications137
h-index32
Citations3,160
Highly Influential Citations84
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In vitro and in vivo antimalarial activities of a non-glycosidic 18-membered macrolide antibiotic, borrelidin, against drug-resistant strains of Plasmodia.
TLDR
The antimalarial profile of borrelidin is reported here, a known nonglycosidic 18-membered macrolide antibiotic with a cyclopentanecarboxylic acid side chain, in comparison with those of clinically used antimalaria drugs.
Borrelidin, a potent antimalarial: stage-specific inhibition profile of synchronized cultures of Plasmodium falciparum
Borrelidin, a potent antimalarial: stage-specific inhibition profile of synchronized cultures of Plasmodium falciparum
In vitro antimalarial activity of biflavonoids from Wikstroemia indica.
TLDR
In this investigation of in vitro antimalarial screening of medicinal herbal extracts, the n-BuOH extract from the root of Wikstroemia indica showed a potent inhibitory effect and two biflavonoids were isolated, 1 and 2 of which were confirmed by (1)H- and (13)C-NMR.
New lycorine-type alkaloid from Lycoris traubii and evaluation of antitrypanosomal and antimalarial activities of lycorine derivatives.
Antitrypanosomal activity of some pregnane glycosides isolated from Caralluma species.
Spoxazomicins A–C, novel antitrypanosomal alkaloids produced by an endophytic actinomycete, Streptosporangium oxazolinicum K07-0460T
TLDR
Three novel antitrypanosomal alkaloids were isolated by silica gel column chromatography and HPLC from the culture broth of a new endophytic actinomycete species and shown to be new types of pyochelin family antibiotic.
Potent antimalarial activities of polyether antibiotic, X-206.
TLDR
Comparison of biological activities and ion-affinities of the above antibiotics suggests that monovalent cations play an important biological role for the intracellular growth of P. falciparum in parasitized erythrocytes.
Acylated pregnane glycosides from Caralluma tuberculata and their antiparasitic activity.
In vitro antimalarial activity of prenylated flavonoids from Erythrina fusca
TLDR
Ethyl acetate extract from the stem bark of Erythrina fusca showed a antimalarial activity against the multi-drug-resistant strain (K1) of Plasmodium falciparum, and six flavonoids, lupinifolin, citflavanone, erythrisenegalone, lonchocarpol A, and 8-prenyldaidzein were isolated from the extract.
Antiplasmodial and antitrypanosomal activity of plants from the Kingdom of Saudi Arabia
TLDR
The antiplasmodial and antitrypanosomal activity of the methanol extracts of 42 plants collected from the Kingdom of Saudi Arabia and some fractions obtained thereof were evaluated and the cytotoxicity of the active extracts was also evaluated against the MRC5 human cell line.
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