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morphine biosynthetic process

Known as: morphine anabolism, morphine synthesis, morphine formation 
The chemical reactions and pathways resulting in the formation of morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine… 
National Institutes of Health

Papers overview

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2017
2017
Little girl link dropbox Codeine and methadone interactions
  • 2017
  • Corpus ID: 13266721
Cytochrome P450; Drug Interactions; CYP3A4; CYP2D6; Metabolites; Opioids. Introduction metabolism of codeine, fentanyl, methadone… 
2015
2015
A and morphine synthesis 1 Cytochrome P 450 3 A Enzymes Catalyze the O 6-Demethylation of Thebaine , a Key Step in Endogenous Mammalian Morphine Biosynthesis
Morphine, first characterized in opium from the poppy Papaver somniferum, is one of the strongest known analgesics. Endogenous… 
2013
2013
Alkaloid Metabolism in Opium Poppy Widespread Roles in Benzylisoquinoline-Demethylenation with O , O and Demethylation O-Dioxygenases Catalyze Plant Biology :
2011
2011
Detection of substrate binding motifs for morphine biosynthetic pathway intermediates in novel wound inducible (R,S)-reticuline 7-O-methyltransferase of Papaver somniferum
The benzylisoquinoline alkaloids (BIA) comprise a large and diverse group of nitrogen-containing secondary metabolites with about… 
2010
2010
Regulation of the Transcription of the Catechol-O- Methyltransferase Gene by Morphine and Epinephrine
Changes in relative mRNA expression of catechol-O-methyltransferase (COMT) in cells treated with morphine and epinephrine were… 
2008
2008
CYP2D6: a key enzyme in morphine synthesis in animals.
Our laboratory and others have demonstrated that animals can make morphine, meaning its biosynthetic pathway has been conserved… 
2003
2003
HYPOTHALAMIC DIGOXIN AND HEMISPHERIC CHEMICAL DOMINANCE: RELATION TO ALCOHOLIC ADDICTION, ALCOHOLIC CIRRHOSIS, AND ACQUIRED HEPATOCEREBRAL DEGENERATION
The isoprenoid pathway produces three key metabolites--endogenous digoxin (modulate tryptophan/tyrosine transport), dolichol… 
2002
2002
Diacetylmorphine degradation to 6-monoacetylmorphine and morphine in cell culture: implications for in vitro studies.
2000
2000
Quantitiative prediction of drug interactions. Inhibition of morphine formation from codeine (CYP2D6)and substrate binding/uptake in rat microsomes and hepatocytes.
1998
1998
Morphine formation from ethylmorphine: implications for drugs-of-abuse testing in urine.
In drugs-of-abuse testing, opiates constitute a delicate and controversial task because morphine may occur in urine for several… 
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