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metyrapol

Known as: 2-methyl-1,2-bis(3-pyridyl)-1-propanol 
National Institutes of Health

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Metyrapone

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SU-5236
analogs & derivatives

Papers overview

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2013
2013
[(3)H]metyrapol and 4-[(131)i]iodometomidate label overlapping, but not identical, binding sites on rat adrenal membranes.
Metyrapone, metyrapol, and etomidate are competitive inhibitors of 11-deoxycorticosterone hydroxylation by 11β-hydroxylase. [(3)H… 
2002
2002
Determination of the plasma levels of metyrapone and its enantiomeric metyrapol metabolites by direct plasma injection and multidimensional achiral-chiral chromatography.
The development and validation of a direct injection high-performance liquid chromatographic (HPLC) method, with column switching… 
1997
1997
Stereoselective reductive metabolism of metyrapone and inhibitory activity of metyrapone metabolites, metyrapol enantiomers, on steroid 11 beta-hydroxylase in the rat.
Pharmacokinetics of metyrapone and metyrapol enantiomers was studied in the rat to determine the stereoselective reductive… 
1992
1992
Characterization of carbonyl reducing activity in continuous cell lines of human and rodent origin.
1991
1991
Reductive metabolism of metyrapone by a quercitrin-sensitive ketone reductase in mouse liver cytosol.
1991
1991
Heterogeneity of carbonyl reduction in subcellular fractions and different organs in rodents.
1991
1991
Carbonyl reduction of metyrapone in human liver.
1985
1985
Alteration of the inhibitory effect of metyrapone by reduction to metyrapol during the metabolism of methacetin in vivo in mice
SummaryMetyrapone is known as an inhibitor of the oxidative drug metabolism in vitro. We have used the exhalation analysis as a… 
1981
1981
Metabolism of metyrapone. 2-Chromatographic and mass spectral properties of the N-oxides of metyrapone and metyrapol.
Electron impact mass spectral studies on the mono- and di-N-oxides of metyrapone and metyrapol revealed that the technique… 
1968
1968
The reduction of SU-4885 by adrenal glands and other tissues and its inhibition by ACTH.
Rat adrenal glands convert 2-methyl-1,2-bis(3-pyridyl)-1-propanone (SU-4885) in vitro to a product with physical and chemical… 
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