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Effect of delta9-tetrahydrocannabinol on mitochondrial NADH-oxidase activity.
Delta9-Tetrahydrocannabinol (delta9-THC), the active ingredient of marihuana was found to be a highly effective inhibitor in vitro of the NADH-oxidase activity of rat brain and heart mitochondria.
THE EFFECT OF CYPROHEPTADINE ON THE RELEASE OF CORTICOTROPHIN RELEASING FACTOR
TLDR
Results suggest that cyproheptadine reduces the high circulating levels of ACTH in some patients suffering from Cushing's disease and Nelson's syndrome by inhibiting CRF secretion.
EFFECTS OF CALCIUM ON THE POTASSIUM AND SODIUM CONTENT OF RAT ADRENAL GLANDS, ON THE STIMULATION OF STEROID PRODUCTION BY ADENOSINE 3′,5′-MONOPHOSPHATE, AND ON THE RESPONSE OF THE ADRENAL TO SHORT
The potassium content of incubated rat adrenal tissue is significantly higher when calcium is present in the incubation medium than when it is absent. The effect of calcium on the sodium content of
Distribution, metabolism and biological activity of deoxycorticosterone in the central nervous system
TLDR
Data from the eviscerated rat point to a uniform distribution of [1,2-3H]DOC in neural tissues and suggest that the higher levels of radioactivity found in the brain stem may be due to a DOC metabolite with the chromatographic characteristics of allo-tetrahydro-DOC, an anaesthetic-type steroid.
Steroid secretion by rat adrenal glands during the first week following adrenal enucleation.
TLDR
The relative increase in the amount of DOC available to the rats bearing regenerating adrenal glands might contribute to the sodium retention observed in these rats during the first week after adrenal regeneration.
The effect of pH on the respiration of brain tissue; the pH of tissue slices.
TLDR
It is concluded that the true optimum pH for the respiration of brain tissue is in the usual physiological range and that the actual pH within slices is usually appreciably different from that of the medium in which they are immersed.
Reduction by Δ9‐ tetrahydrocannabinol in the blood pressure of hypertensive rats bearing regenerated adrenal glands
TLDR
Delta(9)-THC, at a moderate dose for the rat, is capable of lowering the blood pressure in rats suffering from adrenal regeneration hypertension and that chronic administration of Delta(9-THC does not appear to stimulate the pituitary-adrenal axis, in contrast to reported effects of acute administration.
Adrenal steroid biosynthesis by different species of mouselike rodents.
TLDR
Evidence for the endogenous formation of aldosterone and 18-hydroxycorticosterone was obtained in all the species, and the identity of these compounds was established when they were present as radioactive conversion products.
Inactivation of ACTH by isolated rat adrenals and inhibition of corticoid formation by adrenocortical hormones.
TLDR
Concentrations of corticoid as low as 10-5 M are inhibitory, indicating the possibility that the inhibition of the pituitary-adrenal system by adrenal cortical ...
Hypertensive Action of 18-Hydroxydeoxycorticosterone
TLDR
Daily subcutaneous injections of 200 micrograms, a low physiological dose, significantly increase the blood pressure of unilaterally nephrectomized saline-treated rats after 2 weeks, which strengthens the hypothesis that 18-hydroxydeoxycorticosterone contributes to the etiology of hypertension, possibly by a mechanism involving stressinduced release of adrenocorticotropic hormone.
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