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methylpyrazole

 
National Institutes of Health

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pyrazole

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2007
2007
Scaffold hopping, synthesis and structure-activity relationships of 5,6-diaryl-pyrazine-2-amide derivatives: a novel series of CB1 receptor antagonists.
A scaffold hopping approach has been exploited to design a novel class of cannabinoid (CB1) receptor antagonists for the… Expand
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2007
2007
Topiramate (Topamax) reduces conditioned abstinence behaviours and handling-induced convulsions (HIC) after chronic administration of alcohol in Swiss-Webster mice.
UNLABELLED Topiramate has emerged as one of the promising drugs for the treatment of alcoholism and alcohol addiction. Recent… Expand
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2007
2007
Pyrazole and methylpyrazole for the treatment of 2-butoxyethanol poisoning.
2-Butoxyethanol (BE) is a one member of a family of ethylene glycol monoalkyl ethers that are used in a variety of industrial and… Expand
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2006
2006
Formation of formaldehyde and malonaldehyde by photooxidation of squalene
Formaldehyde and malonaldehyde were identified upon exposure of squalene to ultraviolet (UV) irradiation at 300 nm. Formaldehyde… Expand
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2000
2000
Toxicokinetics of ethylene glycol during fomepizole therapy: implications for management. For the Methylpyrazole for Toxic Alcohols Study Group.
STUDY OBJECTIVE The elimination kinetics of ethylene glycol (EG) in human subjects treated with fomepizole (4-methylpyrazole… Expand
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Highly Cited
1999
Highly Cited
1999
Fomepizole for the treatment of ethylene glycol poisoning. Methylpyrazole for Toxic Alcohols Study Group.
BACKGROUND Ethylene glycol poisoning causes metabolic acidosis and renal failure and may cause death. The standard treatment is… Expand
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1991
1991
Hepatic transmethylation and blood alcohol levels.
Golden Syrian hamsters that have elevated hepatic alcohol dehydrogenase activity were divided into four groups and group-fed on… Expand
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1987
1987
Monoclonal antibodies to ethanol-induced rat liver cytochrome P-450 that metabolizes aniline and nitrosamines.
Hybridomas were prepared from mouse myeloma cells and spleen cells derived from female BALB/c mice that had been immunized with a… Expand
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1979
1979
Pyrazoles as inhibitors of alcohol oxidation and as important tools in alcohol research: an approach to therapy against methanol poisoning.
4-Methylpyrazole, in a dose producing inhibition of alcohol dehydrogenase (alcohol:NAD(+) oxidoreductase, EC 1.1.1.1), was given… Expand
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1970
1970
Inhibitory effect on ethanol oxidation in man after administration of 4-methylpyrazole.
Abstract The effect of 4-methylpyrazole on the metabolism of ethanol has been examined in 5 healthy male volunteers after oral… Expand
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