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methylpyrazole
National Institutes of Health
Topic mentions per year
Topic mentions per year
1971-2015
0
2
4
1971
2015
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pyrazole
Related mentions per year
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1946-2018
1940
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2020
methylpyrazole
pyrazole
Papers overview
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2011
2011
Combination of two pharmacophoric systems: synthesis and pharmacological evaluation of spirocyclic pyranopyrazoles with high σ₁ receptor affinity.
Torsten Schläger
,
Dirk Schepmann
,
+4 authors
Bernhard Wünsch
Journal of medicinal chemistry
2011
The novel class of spirocyclic σ(1) ligands 3 (6',7'-dihydro-1'H-spiro[piperidine-4,4'-pyrano[4,3-c]pyrazoles]) was designed by…
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2007
2007
Topiramate (Topamax) reduces conditioned abstinence behaviours and handling-induced convulsions (HIC) after chronic administration of alcohol in Swiss-Webster mice.
Justin M. Farook
,
Dennis J Morrell
,
Ben A. Lewis
,
John Martin Littleton
,
S. Barron
Alcohol and alcoholism
2007
UNLABELLED Topiramate has emerged as one of the promising drugs for the treatment of alcoholism and alcohol addiction. Recent…
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2007
2007
Scaffold hopping, synthesis and structure-activity relationships of 5,6-diaryl-pyrazine-2-amide derivatives: a novel series of CB1 receptor antagonists.
Jonas Boström
,
Kristina Berggren
,
Thomas Elebring
,
Peter J Greasley
,
Michael Wilstermann
Bioorganic & medicinal chemistry
2007
A scaffold hopping approach has been exploited to design a novel class of cannabinoid (CB1) receptor antagonists for the…
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2004
2004
Characterization of enzymes responsible for biotransformation of the new antileukotrienic drug quinlukast in rat liver microsomes and in primary cultures of rat hepatocytes.
Barbora Szotáková
,
Lenka Skálová
,
+4 authors
Vladimir Wsol
The Journal of pharmacy and pharmacology
2004
The promising new drug quinlukast, 4-(4-(quinoline-2'-yl-methoxy)phenylsulphanyl)benzoic acid (VUFB 19363), is under…
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1998
1998
Bumetanide-sensitive cell swelling mediates the inhibitory effect of ethanol on proteolysis in rat liver.
Stephan vom Dahl
,
Dr. K. Häußinger
Gastroenterology
1998
BACKGROUND & AIMS Ethanol is known to inhibit proteolysis and to cause intracellular protein accumulation in the liver. The aim…
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1992
1992
Potentiation of adriamycin toxicity by ethanol in perfused rat liver.
Y. Liu
,
Robert Thurman
The Journal of pharmacology and experimental…
1992
Adriamycin, which has a quinone nucleus, damages periportal regions of the lobule in perfused rat liver in an oxygen-dependent…
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1991
1991
Hepatic transmethylation and blood alcohol levels.
Anthony J. Barak
,
Harriet C Beckenhauer
,
Dean J. Tuma
Alcohol and alcoholism
1991
Golden Syrian hamsters that have elevated hepatic alcohol dehydrogenase activity were divided into four groups and group-fed on…
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1988
1988
Acute inhibition by ethanol of intestinal absorption of glucose and hepatic glycogen synthesis on glucose refeeding after starvation in the rat.
E B Cook
,
Jennifer Preece
,
Shelagh Tobin
,
Mary C. Sugden
,
D. Cox
,
T Norman Palmer
The Biochemical journal
1988
1. Intragastric administration of ethanol (75 mmol/kg body wt.) at 1 h before glucose refeeding of 24 h-starved rats inhibited…
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1987
1987
Monoclonal antibodies to ethanol-induced rat liver cytochrome P-450 that metabolizes aniline and nitrosamines.
In-Young Ko
,
S. S. Park
,
+5 authors
H. V. Gelboin
Cancer research
1987
Hybridomas were prepared from mouse myeloma cells and spleen cells derived from female BALB/c mice that had been immunized with a…
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1975
1975
Significant pathways of hepatic ethanol metabolism.
Robert Thurman
,
William R. McKenna
,
H. James Brentzel
,
S. Hesse
Federation proceedings
1975
Rat liver microsomes oxidized ethanol two to three times faster than propanol when incubated with either an NADPH- or an H2O2…
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