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methylpyrazole

 
National Institutes of Health

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pyrazole

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2011
2011
Combination of two pharmacophoric systems: synthesis and pharmacological evaluation of spirocyclic pyranopyrazoles with high σ₁ receptor affinity.
The novel class of spirocyclic σ(1) ligands 3 (6',7'-dihydro-1'H-spiro[piperidine-4,4'-pyrano[4,3-c]pyrazoles]) was designed by… Expand
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Highly Cited
2007
Highly Cited
2007
Scaffold hopping, synthesis and structure-activity relationships of 5,6-diaryl-pyrazine-2-amide derivatives: a novel series of CB1 receptor antagonists.
A scaffold hopping approach has been exploited to design a novel class of cannabinoid (CB1) receptor antagonists for the… Expand
2006
2006
Methylpyrazole-capped two-dimensional supramolecular M(II) (M = Mn, Ni, Co) assemblies constructed by covalent and noncovalent interactions: uncommon coordination modes of methylpyrazoles and…
Two mononuclear complexes [Mn(5-methylpyrazole)4(N3)2] (1) and [Ni(5-methylpyrazole)4(N3)2] (2), as well as a novel one… Expand
2006
2006
Formation of formaldehyde and malonaldehyde by photooxidation of squalene
Formaldehyde and malonaldehyde were identified upon exposure of squalene to ultraviolet (UV) irradiation at 300 nm. Formaldehyde… Expand
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Highly Cited
2000
Highly Cited
2000
Toxicokinetics of ethylene glycol during fomepizole therapy: implications for management. For the Methylpyrazole for Toxic Alcohols Study Group.
STUDY OBJECTIVE The elimination kinetics of ethylene glycol (EG) in human subjects treated with fomepizole (4-methylpyrazole… Expand
Highly Cited
1999
Highly Cited
1999
Fomepizole for the treatment of ethylene glycol poisoning. Methylpyrazole for Toxic Alcohols Study Group.
BACKGROUND Ethylene glycol poisoning causes metabolic acidosis and renal failure and may cause death. The standard treatment is… Expand
Highly Cited
1987
Highly Cited
1987
Monoclonal antibodies to ethanol-induced rat liver cytochrome P-450 that metabolizes aniline and nitrosamines.
Hybridomas were prepared from mouse myeloma cells and spleen cells derived from female BALB/c mice that had been immunized with a… Expand
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Highly Cited
1979
Highly Cited
1979
Pyrazoles as inhibitors of alcohol oxidation and as important tools in alcohol research: an approach to therapy against methanol poisoning.
4-Methylpyrazole, in a dose producing inhibition of alcohol dehydrogenase (alcohol:NAD(+) oxidoreductase, EC 1.1.1.1), was given… Expand
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1974
1974
Effects of pyrazole, 4-bromopyrazole and 4-methylpyrazole on mitochondrial function.
Abstract Pyrazole, an inhibitor of alcohol dehydrogenase, has been widely used in studies of ethanol metabolism. Since its… Expand
Highly Cited
1970
Highly Cited
1970
Inhibitory effect on ethanol oxidation in man after administration of 4-methylpyrazole.
Abstract The effect of 4-methylpyrazole on the metabolism of ethanol has been examined in 5 healthy male volunteers after oral… Expand
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