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methylpyrazole

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1971-2015
02419712015

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pyrazole

Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
methylpyrazole
pyrazole

Papers overview

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2011
2011
Combination of two pharmacophoric systems: synthesis and pharmacological evaluation of spirocyclic pyranopyrazoles with high σ₁ receptor affinity.
The novel class of spirocyclic σ(1) ligands 3 (6',7'-dihydro-1'H-spiro[piperidine-4,4'-pyrano[4,3-c]pyrazoles]) was designed by… (More)
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2007
2007
Topiramate (Topamax) reduces conditioned abstinence behaviours and handling-induced convulsions (HIC) after chronic administration of alcohol in Swiss-Webster mice.
UNLABELLED Topiramate has emerged as one of the promising drugs for the treatment of alcoholism and alcohol addiction. Recent… (More)
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2007
2007
Scaffold hopping, synthesis and structure-activity relationships of 5,6-diaryl-pyrazine-2-amide derivatives: a novel series of CB1 receptor antagonists.
A scaffold hopping approach has been exploited to design a novel class of cannabinoid (CB1) receptor antagonists for the… (More)
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2004
2004
Characterization of enzymes responsible for biotransformation of the new antileukotrienic drug quinlukast in rat liver microsomes and in primary cultures of rat hepatocytes.
The promising new drug quinlukast, 4-(4-(quinoline-2'-yl-methoxy)phenylsulphanyl)benzoic acid (VUFB 19363), is under… (More)
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1998
1998
Bumetanide-sensitive cell swelling mediates the inhibitory effect of ethanol on proteolysis in rat liver.
BACKGROUND & AIMS Ethanol is known to inhibit proteolysis and to cause intracellular protein accumulation in the liver. The aim… (More)
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1992
1992
Potentiation of adriamycin toxicity by ethanol in perfused rat liver.
Adriamycin, which has a quinone nucleus, damages periportal regions of the lobule in perfused rat liver in an oxygen-dependent… (More)
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1991
1991
Hepatic transmethylation and blood alcohol levels.
Golden Syrian hamsters that have elevated hepatic alcohol dehydrogenase activity were divided into four groups and group-fed on… (More)
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1988
1988
Acute inhibition by ethanol of intestinal absorption of glucose and hepatic glycogen synthesis on glucose refeeding after starvation in the rat.
1. Intragastric administration of ethanol (75 mmol/kg body wt.) at 1 h before glucose refeeding of 24 h-starved rats inhibited… (More)
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1987
1987
Monoclonal antibodies to ethanol-induced rat liver cytochrome P-450 that metabolizes aniline and nitrosamines.
Hybridomas were prepared from mouse myeloma cells and spleen cells derived from female BALB/c mice that had been immunized with a… (More)
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1975
1975
Significant pathways of hepatic ethanol metabolism.
Rat liver microsomes oxidized ethanol two to three times faster than propanol when incubated with either an NADPH- or an H2O2… (More)
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