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melarsen oxide

Known as: melarsenoxide, p-(4,6-diamino-1,3,5-triazin-2-yl)aminophenylarsonous acid 
National Institutes of Health

Related topics

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1 relation

Broader (1)

Arsenicals

Papers overview

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2000
2000
A potential target enzyme for trypanocidal drugs revealed by the crystal structure of NAD-dependent glycerol-3-phosphate dehydrogenase from Leishmania mexicana.
Highly Cited
2000
Highly Cited
2000
Inactivation of calcineurin by hydrogen peroxide and phenylarsine oxide. Evidence for a dithiol-disulfide equilibrium and implications for redox regulation.
Calcineurin (CaN) is a Ca2+-and calmodulin (CaM)-dependent serine/threonine phosphatase containing a dinuclear Fe-Zn center in… 
2000
2000
Further evidence for a link between melarsoprol resistance and P2 transporter function in African trypanosomes.
Highly Cited
1995
Highly Cited
1995
Uptake of Diamidine Drugs by the P2 Nucleoside Transporter in Melarsen-sensitive and -resistant Trypanosoma brucei brucei(*)
The African trypanosome, Trypanosoma brucei brucei, possesses at least two nucleoside transporter systems designated P1 and P2… 
Highly Cited
1992
Highly Cited
1992
Characterisation of melarsen-resistant Trypanosoma brucei brucei with respect to cross-resistance to other drugs and trypanothione metabolism.
1991
1991
Differential sensitivity of Trypanosoma brucei rhodesiense isolates to in vitro lysis by arsenicals.
Highly Cited
1989
Highly Cited
1989
Trypanothione is the primary target for arsenical drugs against African trypanosomes.
The trypanosomatid metabolite N1,N8-bis-(glutathionyl)spermidine (trypanothione) has been demonstrated to form a stable adduct… 
Highly Cited
1985
Highly Cited
1985
Leishmania mexicana: enzyme activities of amastigotes and promastigotes and their inhibition by antimonials and arsenicals.
Highly Cited
1978
Highly Cited
1978
An approach to the development of new drugs for African trypanosomiasis
The inability of the bloodstream form of Trypanosoma brucei brucei to decompose hydrogen peroxide forms the basis of our attempt… 
Highly Cited
1977
Highly Cited
1977
Trypanosoma brucei: suramin and other trypanocidal compounds' effects on sn-glycerol-3-phosphate oxidase.
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