• Publications
  • Influence
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
TLDR
The epimastigote form of Trypanosoma cruzi differs significantly from the African trypanosomes and Leishmania in being unable to synthesise significant amounts of diamines de novo, and convertingsignificant amounts of putrescine and cadaverine to spermine and bis(aminopropyl)cADAverine, respectively and the ability to synthesised homotrypanothione as well as trypanothsione. Expand
The interaction of arsenical drugs with dihydrolipoamide and dihydrolipoamide dehydrogenase from arsenical resistant and sensitive strains of Trypanosoma brucei brucei.
TLDR
Findings implicate lipoic acid, but not dihydrolipoamide dehydrogenase, in resistance to arsenical drugs, either through the mechanism of uptake or as the final target of these drugs. Expand
Inhibition of polyamine biosynthesis in Crithidia fasciculata by D,L-α-difluoromethylornithine and D,L-α-difluoromethylarginine
TLDR
DFMA appears to inhibit growth of C. fasciculata via conversion to DFMO and subsequent inhibition of ODC, suggesting that the site of inhibition is ornithine decarboxylase (ODC). Expand
The photoreduction of H(2)O(2) by Synechococcus sp. PCC 7942 and UTEX 625.
TLDR
The measured in vivo activity of a light-dependent peroxidase in Synechococcus sp. Expand
Inhibition of polyamine biosynthesis in Crithidia fasciculata by D,L-alpha-difluoromethylornithine and D,L-alpha-difluoromethylarginine.
TLDR
DFMA appears to inhibit growth of C. fasciculata via conversion to DFMO and subsequent inhibition of ODC, suggesting that the site of inhibition is ornithine decarboxylase (ODC). Expand
Phenotype of recombinant Leishmania donovani and Trypanosoma cruzi which over-express trypanothione reductase. Sensitivity towards agents that are thought to induce oxidative stress.
TLDR
The experiments suggest that the ability to regenerate dihydrotrypanothione from trypanothsione disulphide is not a rate-limiting step in the metabolism of hydrogen peroxide. Expand
A dansyl chloride-HPLC method for the determination of polyamines.
  • K. Hunter
  • Chemistry, Medicine
  • Methods in molecular biology
  • 1998
Changes in the glutathione content of rat 9L cells induced by treatment with the ornithine decarboxylase inhibitor alpha-difluoromethylornithine.
TLDR
Incubation of cells with DFMO for longer periods caused an increase in glutathione that is related to the depletion of polyamines and not to a decrease in growth rate or a cell cycle effect, but rather to an apparent increase in the rate of synthesis of the tripeptide. Expand
Reduction in cis-diamminedichloroplatinum(II)-induced cytotoxicity, sister chromatid exchange, and DNA interstrand cross-links in 9L cells treated with the polyamine biosynthesis inhibitor
TLDR
Several mechanisms by which polyamine depletion could reduce cis-diamminedichloroplatinum(II) toxicity are discussed, including inhibition of sister chromatid exchanges and DNA interstrand cross-links. Expand
Effect of alpha-difluoromethylornithine on 1,3-bis(2-chloroethyl)-1-nitrosourea and cis-diamminedichloroplatinum(II) cytotoxicity, DNA interstrand cross-linking, and growth in human brain tumor cell
TLDR
The polyamine biosynthesis inhibitor alpha-difluoromethylornithine was studied in vitro in U-251 MG and SF-126 cells, human tumor cell lines derived from malignant glioma tissue to study the effect of DFMO treatment on cell growth and potentiation of cytotoxicity. Expand
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