mandelylthiamin
National Institutes of Health
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Mandelylthiamin (1) is a conjugate of benzoylformate and thiamin that loses CO2 to form the classic Breslow intermediate (2…
Mandelylthiamin (MTh) is an accurate model of the pre-decarboxylation intermediate formed on benzoylformate decarboxylase (BFDC…
The decarboxylation of mandelylthiamin is subject to general base catalysis (β = 0.26), an outcome that is inconsistent with the…
Decarboxylation of mandelylthiamin in aqueous solution is analyzed by means of quantum mechanics/molecular mechanics simulations…
The mechanism of decarboxylations in water and the catalysis of mandelylthiamin (MTh) decarboxylation by pyridinium ions is…
It has been proposed that the decarboxylation of mandelylthiamin, the adduct of benzoylformate and thiamin, is uniquely catalyzed…
Mandelylthiamin (MT) is formally the conjugate of thiamin and benzoylformate. It is the simplified analogue of the first covalent…
The conjugate of thiamin and benzoylformate, mandelylthiamin (MTh), undergoes decarboxylation about 106 times slower than the…