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mandelylthiamin

 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Lessons Learned from the Reactivity of Mandelylthiamin and Derivatives
Mandelylthiamin (MTh) is an accurate model of the pre-decarboxylation intermediate formed on benzoylformate decarboxylase (BFDC… Expand
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2017
2017
The Need for an Alternative to Radicals as the Cause of Fragmentation of a Thiamin-Derived Breslow Intermediate.
Mandelylthiamin (1) is a conjugate of benzoylformate and thiamin that loses CO2 to form the classic Breslow intermediate (2… Expand
2015
2015
Lithium-stabilized nucleophilic addition of thiamin to a ketone provides an efficient route to mandelylthiamin, a critical pre-decarboxylation intermediate.
Mandelylthiamin (MTh) is an accurate model of the covalent intermediate derived from the condensation of thiamin diphosphate and… Expand
2012
2012
Base-catalyzed decarboxylation of mandelylthiamin: direct formation of bicarbonate as an alternative to formation of CO2.
The decarboxylation of mandelylthiamin is subject to general base catalysis (β = 0.26), an outcome that is inconsistent with the… Expand
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2012
2012
Reversibility and diffusion in mandelythiamin decarboxylation. Searching dynamical effects in decarboxylation reactions.
Decarboxylation of mandelylthiamin in aqueous solution is analyzed by means of quantum mechanics/molecular mechanics simulations… Expand
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2010
2010
Isotope effect, mechanism, and origin of catalysis in the decarboxylation of mandelylthiamin.
The mechanism of decarboxylations in water and the catalysis of mandelylthiamin (MTh) decarboxylation by pyridinium ions is… Expand
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2009
2009
Internal return of carbon dioxide in decarboxylation: catalysis of separation and 12C/13C kinetic isotope effects.
It has been proposed that the decarboxylation of mandelylthiamin, the adduct of benzoylformate and thiamin, is uniquely catalyzed… Expand
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2006
2006
Accelerating unimolecular decarboxylation by preassociated acid catalysis in thiamin-derived intermediates: implicating Brønsted acids as carbanion traps in enzymes.
Mandelylthiamin (MT) is formally the conjugate of thiamin and benzoylformate. It is the simplified analogue of the first covalent… Expand
2005
2005
Making thiamin work faster: acid-promoted separation of carbon dioxide.
  • Q. Hu, R. Kluger
  • Journal of the American Chemical Society
  • 2005
    • Corpus ID: 30333319
The conjugate of thiamin and benzoylformate, mandelylthiamin (MTh), undergoes decarboxylation about 106 times slower than the… Expand
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