Isotope effect, mechanism, and origin of catalysis in the decarboxylation of mandelylthiamin.

@article{GonzalezJames2010IsotopeEM,
  title={Isotope effect, mechanism, and origin of catalysis in the decarboxylation of mandelylthiamin.},
  author={Ollie M Gonzalez-James and D. A. Singleton},
  journal={Journal of the American Chemical Society},
  year={2010},
  volume={132 20},
  pages={
          6896-7
        }
}
The mechanism of decarboxylations in water and the catalysis of mandelylthiamin (MTh) decarboxylation by pyridinium ions is explored. It has been recently proposed that a decarboxylation step forming an intermediate molecule/CO(2) pair is reversible and that pyridinium ions catalyze the MTh decarboxylation by trapping the intermediate, preventing reversion to MTh. A calculation of the barrier for the back reaction goes against this proposal, as the diffusional separation of CO(2) would be on… Expand
26 Citations
Decarboxylation, CO2 and the reversion problem.
  • R. Kluger
  • Chemistry, Medicine
  • Accounts of chemical research
  • 2015
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