Corpus ID: 103790539

Lessons Learned from the Reactivity of Mandelylthiamin and Derivatives

@inproceedings{Bielecki2017LessonsLF,
  title={Lessons Learned from the Reactivity of Mandelylthiamin and Derivatives},
  author={M. Bielecki},
  year={2017}
}
Mandelylthiamin (MTh) is an accurate model of the pre-decarboxylation intermediate formed on benzoylformate decarboxylase (BFDC). In solution, it decarboxylates to the Breslow intermediate 10 times slower than on the enzyme. Earlier studies proposed that the C–C bond-breaking step in the decarboxylation of MTh is highly reversible, and thus possibly impeding the overall reaction rate. More recently, it was observed that the decarboxylation of MTh could be more effective through formation of… Expand