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lotrafiban

 
National Institutes of Health

Papers overview

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2010
2010
Migration of megakaryocytes (MKs) from the proliferative osteoblastic niche to the capillary-rich vascular niche is essential for… Expand
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2010
2010
Summary.  Background: The integrin αIIbβ3 is the major mediator of platelet aggregation and has, therefore, become an important… Expand
Highly Cited
2003
Highly Cited
2003
Background—This is the primary report of the large-scale evaluation of lotrafiban, an orally administered IIb/IIIa receptor… Expand
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2003
2003
Summary.  We have compared the roles of adenosine diphosphate (ADP), thromboxanes and the integrin α2β1 in the activation of… Expand
2003
2003
Activation of human platelets by thrombin is mediated by the proteolytic cleavage of two G‐protein coupled protease‐activated… Expand
2002
2002
Platelet accretion into arterial thrombus in stenotic arterial vessels involves shear-induced platelet activation and adhesion… Expand
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2001
2001
Our objective was to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of lotrafiban, an oral glycoprotein… Expand
2000
2000
BACKGROUND Antiplatelet therapy is the mainstay of the treatment and secondary prevention of cardiovascular and cerebrovascular… Expand
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Review
2000
Review
2000
Platelets play a major role in thrombus formation, as well as in the pathogenesis of atherothrombosis. Inhibition of platelet… Expand
Highly Cited
2000
Highly Cited
2000
BACKGROUND Platelets play a key role in the pathogenesis of atherosclerosis, thrombosis, and acute coronary and cerebrovascular… Expand