lotrafiban
National Institutes of Health
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Thromboembolic events (TEE) underwrite key causes of death in developed countries. While advanced imaging technologies such as…
Summary. Background: The integrin αIIbβ3 is the major mediator of platelet aggregation and has, therefore, become an important…
Controversial results have been reported concerning the ability of fibrinogen receptor antagonists (fibans) to induce…
Collagen and collagen-related peptide (CRP) activate platelets by interacting with glycoprotein (GP)VI. In addition, collagen…
Collagen and collagen-related peptide (CRP) activate platelets by interacting with glycoprotein (GP)VI. In addition, collagen…
Gp IIb/IIIa receptor antagonists are potent antiplatelet agents since they block the final pathway in platelet aggregation…
We have compared the roles of adenosine diphosphate (ADP), thromboxanes and the integrin alpha(2)beta(1) in the activation of…
Our objective was to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of lotrafiban, an oral glycoprotein…
Platelets play a major role in thrombus formation, as well as in the pathogenesis of atherothrombosis. Inhibition of platelet…