lotrafiban
National Institutes of Health
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Migration of megakaryocytes (MKs) from the proliferative osteoblastic niche to the capillary-rich vascular niche is essential for…
Summary. Background: The integrin αIIbβ3 is the major mediator of platelet aggregation and has, therefore, become an important…
Controversial results have been reported concerning the ability of fibrinogen receptor antagonists (fibans) to induce…
Activation of human platelets by thrombin is mediated by the proteolytic cleavage of two G‐protein coupled protease‐activated…
Summary. We have compared the roles of adenosine diphosphate (ADP), thromboxanes and the integrin α2β1 in the activation of…
Platelet accretion into arterial thrombus in stenotic arterial vessels involves shear-induced platelet activation and adhesion…
Our objective was to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of lotrafiban, an oral glycoprotein…
BACKGROUND
Antiplatelet therapy is the mainstay of the treatment and secondary prevention of cardiovascular and cerebrovascular…
Platelets play a major role in thrombus formation, as well as in the pathogenesis of atherothrombosis. Inhibition of platelet…
BACKGROUND
Platelets play a key role in the pathogenesis of atherosclerosis, thrombosis, and acute coronary and cerebrovascular…