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lotrafiban

 
National Institutes of Health

Papers overview

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2010
2010
BACKGROUND The integrin alpha(IIb)beta(3) is the major mediator of platelet aggregation and has, therefore, become an important… Expand
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2010
2010
Migration of megakaryocytes (MKs) from the proliferative osteoblastic niche to the capillary-rich vascular niche is essential for… Expand
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Highly Cited
2003
Highly Cited
2003
BACKGROUND This is the primary report of the large-scale evaluation of lotrafiban, an orally administered IIb/IIIa receptor… Expand
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2003
2003
1. Activation of human platelets by thrombin is mediated by the proteolytic cleavage of two G-protein coupled protease-activated… Expand
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2002
2002
Platelet accretion into arterial thrombus in stenotic arterial vessels involves shear-induced platelet activation and adhesion… Expand
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2002
2002
In patients with acute coronary syndromes, inhibition of platelet aggregation with parenteral alpha(IIb)/beta(III) antagonists… Expand
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2001
2001
OBJECTIVE Our objective was to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of lotrafiban, an oral… Expand
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Review
2000
Review
2000
Platelets play a major role in thrombus formation, as well as in the pathogenesis of atherothrombosis. Inhibition of platelet… Expand
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2000
2000
BACKGROUND Antiplatelet therapy is the mainstay of the treatment and secondary prevention of cardiovascular and cerebrovascular… Expand
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2000
2000
BACKGROUND Platelets play a key role in the pathogenesis of atherosclerosis, thrombosis, and acute coronary and cerebrovascular… Expand
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