Activation of GPVI by collagen is regulated by alpha2beta1 and secondary mediators.

@article{Atkinson2003ActivationOG,
  title={Activation of GPVI by collagen is regulated by alpha2beta1 and secondary mediators.},
  author={Ben T. Atkinson and Gavin E Jarvis and Stephen P. Watson},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2003},
  volume={1 6},
  pages={
          1278-87
        }
}
We have compared the roles of adenosine diphosphate (ADP), thromboxanes and the integrin alpha(2)beta(1) in the activation of washed platelets by collagen in the presence of the alpha(IIb)beta(3) antagonist lotrafiban. The stimulation of protein tyrosine phosphorylation by a collagen suspension is markedly delayed in the presence of the above inhibitors but shows substantial recovery with time. In comparison, activation of phospholipase C (PLC), Ca(2+) elevation and dense granule secretion are… CONTINUE READING

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