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losartan carboxylic acid

Known as: 1H-imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-((2'-(2H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-, 2-n-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methylll)imidazole-5-carboxylic acid 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

Anti-Arrhythmia AgentsAntihypertensive AgentsLosartan

Narrower (1)

EXP3174

Papers overview

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Highly Cited
2019
Highly Cited
2019
Environmental fate of pharmaceutical compounds and antimicrobial-resistant bacteria in hospital effluents, and contributions to pollutant loads in the surface waters in Japan.
2019
2019
Target quantification of azole antifungals and retrospective screening of other emerging pollutants in wastewater effluent using UHPLC -QTOF-MS.
2018
2018
Conjugation to Ascorbic Acid Enhances Brain Availability of Losartan Carboxylic Acid and Protects Against Parkinsonism in Rats
Identification of renin-angiotensin system in the interplay of hypertension and neurodegeneration has paved the way for the… 
2017
2017
High-throughput quantification of 8 antihypertensive drugs and active metabolites in human plasma using UPLC-MS/MS.
2015
2015
Human Bioequivalence Evaluation of Two Losartan Potassium Tablets Under Fasting Conditions
The bioequivalence of two different tablet formulations containing losartan potassium 100 mg was determined in healthy volunteers… 
2014
2014
Simultaneous LC-MS/MS analysis of the plasma concentrations of a cocktail of 5 cytochrome P450 substrate drugs and their metabolites.
A "cocktail" approach, which involves simultaneous administration of multiple CYP-specific probes, concurrently detects the… 
2012
2012
Liquid chromatography-mass spectrometric determination of losartan and its active metabolite on dried blood spots.
2012
2012
Development of a HPLC method for the determination of losartan urinary metabolic ratio to be used for the determination of CYP2C9 hydroxylation phenotypes
Abstract Background: Losartan is metabolized to losartan carboxylic acid (E-3174) by the polymorphic cytochrome CYP2C9. The aim… 
2009
2009
Bioequivalence model for evaluation of Losartan in human plasma with special reference to drug–metabolite ratio
Losartan and in-vivo active metabolite losartan carboxylic acid (LCA) formation into systemic circulation have been poorly… 
2005
2005
Comparative pharmacokinetics of two tablet formulations of Losartan: bioequivalence assessment
The pharmacokinetic profiles of two brands of losartan 50 mg tablets were compared in 24 healthy adult volunteers after a single… 
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