Skip to search formSkip to main contentSkip to account menu

EXP3174

Known as: E-3174, EXP 3174, EXP-3174 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

losartan carboxylic acid

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Anti-inflammatory and anti-oxidant properties of telmisartan in cultured human umbilical vein endothelial cells.
Highly Cited
2002
Highly Cited
2002
Transgenic anopheline mosquitoes impaired in transmission of a malaria parasite
We thank the patients for contributing to this study; Y. Terado for discussions on immunohistochemistry, K. Tachampa and J. Y… 
Highly Cited
2002
Highly Cited
2002
Pharmacokinetics of losartan and its metabolite E‐3174 in relation to the CYP2C9 genotype
Losartan is metabolized by polymorphic CYP2C9 to E‐3174. Our aim was to evaluate the pharmacokinetics of losartan and E‐3174 in… 
Highly Cited
2001
Highly Cited
2001
Role of CYP2C9 polymorphism in losartan oxidation.
Losartan, an angiotensin II receptor antagonist, is oxidized by hepatic cytochromes P450 to an active carboxylic acid metabolite… 
Review
2000
Review
2000
Newly emerging pharmacologic differences in angiotensin II receptor blockers.
Review
1998
Review
1998
Angiotensin, thirst, and sodium appetite.
Angiotensin (ANG) II is a powerful and phylogenetically widespread stimulus to thirst and sodium appetite. When it is injected… 
Highly Cited
1995
Highly Cited
1995
Pharmacokinetics of losartan, an angiotensin II receptor antagonist, and its active metabolite EXP3174 in humans
Highly Cited
1993
Highly Cited
1993
Angiotensin II is mitogenic in neonatal rat cardiac fibroblasts.
Angiotensin II has been reported to be a hormonal stimulus of cardiac growth, a response that may involve myocyte hypertrophy as… 
Highly Cited
1993
Highly Cited
1993
Pharmacokinetics and biochemical efficacy after single and multiple oral administration of losartan, an orally active nonpeptide angiotensin II receptor antagonist, in humans.
1. The pharmacokinetics and biochemical efficacy of losartan, an orally active nonpeptide angiotensin II (AII) receptor… 
Highly Cited
1990
Highly Cited
1990
Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: an active metabolite of DuP 753, an orally active antihypertensive agent.
This report describes the pharmacology of (2-n-butyl-4-chloro-1- [(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole-5… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)