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lonapalene

Known as: 6-chloro-2,3-dimethoxynaphthalene-1,4-diol diacetate 
National Institutes of Health

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RS 43179

Papers overview

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2004
2004
Release of Lonapalene from Two-Phase Emulsion-Type Ointment Systems
The in vitro release of lonapalene, a novel nonsteroidal antipsoriatic agent, was studied from two-phase emulsion-type ointment… 
Review
2000
Review
2000
Preview of Potential Therapeutic Applications of Leukotriene B4 Inhibitors in Dermatology
This article reviews the mechanisms and potential therapeutic uses of compounds with inhibitory effects on leukotriene B4 (LTB4… 
1992
1992
Percutaneous Absorption and Metabolism of Lonapalene in Psoriatic Skin
The percutaneous absorption and metabolism of lonapalene (6-chloro-2,3-dimethoxynaphthalene-1,4-diol-diacetate; RS-43179), a… 
1991
1991
High-performance liquid chromatographic determination of the 1,4-diketo and 1,4-diketo-2,3-dihydroxy metabolites of lonapalene in rat urine.
1990
1990
Pharmacologic and clinical effects of lonapalene (RS 43179), a 5-lipoxygenase inhibitor, in psoriasis.
The pharmacologic and clinical effects of the 5-lipoxygenase inhibitor, lonapalene, have been determined in a double-blind… 
1989
1989
Effect of lonapalene on metabolism of exogenous arachidonic acid in human platelets.
Lonapalene was studied as a topical antipsoriatic agent on the basis of its inhibitory effect on 5-lipoxygenase. We studied the… 
1989
1989
An enzymatic method for distinguishing the stereoisomers of 12‐hydroxyeicosatetraenoic acid in human epidermis and psoriatic scale
Homogenates of normal human epidermis synthesized 12‐hydroxyeicosatetraenoic acid (12‐HETE) when incubated in vitro with… 
1988
1988
The clinical and pharmacological effect of lonapalene (RS‐43179), a 5‐lipoxygenase inhibitor, applied topically in psoriasis
33 increased in psoriatic cells (011410014) compared with normal cells (003710001) (P < o 001). There was greater conversion both… 
1987
1987
Dermal absorption of lonapalene, a new anti-psoriatic drug.
1987
1987
Dermal absorption of lonapalene, a new anti-psoriatic drug.
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