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Unmet clinical needs in chronic spontaneous urticaria. A GA2LEN task force report 1
A GA2LEN task force report concluded that chronic spontaneous urticaria is a “hidden epidemic” that needs to be addressed to address the unmet clinical needs of patients. Expand
Autoantibodies against the high-affinity IgE receptor as a cause of histamine release in chronic urticaria.
- M. Hide, D. Francis, C. Grattan, J. Hakimi, J. Kochan, M. Greaves
- The New England journal of medicine
- 3 June 1993
Histamine-releasing IgG autoantibodies against the alpha subunit of the high-affinity IgE receptor are present in the circulation of some patients with chronic urticaria. Expand
EAACI/GA2LEN/EDF guideline: definition, classification and diagnosis of urticaria
This guideline covers the definition and classification of urticaria, taking into account the recent progress in identifying causes, eliciting factors and pathomechanisms of this disease. Expand
Clinical classification of itch: a position paper of the International Forum for the Study of Itch.
This is the first version of a clinical classification worked out by the members of the International Forum for the Study of Itch intended to serve as a diagnostic route for better evaluation of patients with chronic pruritus and aims to improve patients' care. Expand
EAACI/GA2LEN/EDF guideline: management of urticaria
The recommended first line treatment are nonsedating H1 antihistamines, but dosages increased up to fourfold over the recommended doses may be necessary for different urticaria subtypes and in view of individual variation in the course of the disease and response to treatment. Expand
Itch: scratching more than the surface.
- R. Twycross, M. Greaves, +4 authors Z. Żylicz
- QJM : monthly journal of the Association of…
Drug treatments for itch include rifampicin, colestyramine and 17-alpha alkyl androgens (cholestasis), thalidomide (uraemia), cimetidine and corticosteroids (Hodgkin's lymphoma), paroxetine (paraneoplastic itch), aspirin and paroxETine (polycythaemia vera) and indometacin (some HIV+ patients). Expand
Detection of circulating histamine releasing autoantibodies with functional properties of anti‐IgE in chronic urticaria
- C. Grattan, D. Francis, M. Hide, M. Greaves
- Clinical and experimental allergy : journal of…
- 1 November 1991
It is suggested that histamine releasing autoantibodies are important in the pathogenesis of chronic urticaria by stimulating or facilitating degranulation of basophils and cutaneous mast cells through cross‐linking cell surface IgE receptors. Expand
Chronic idiopathic urticaria: comparison of the clinical features of patients with and without anti-FcepsilonRI or anti-IgE autoantibodies.
- R. Sabroe, P. Seed, D. Francis, R. Barr, A. Black, M. Greaves
- Journal of the American Academy of Dermatology
- 1 March 1999
The presence of autoantibodies indicates a subset of patients with more severe CIU, including patients with chronic idiopathic urticaria and patients with higher itch scores for the most severe episodes of itching. Expand
Pathogenesis of chronic urticaria
The autoimmune subgroup is associated with the IgG anti‐IgE receptor α subunit in 35–40% of patients and IgG self-injury in an additional 5–10% and has a higher evidence of human leucocyte antigen DR alleles associated with autoimmunity and a 25% incidence of antithyroid antibodies with diagnosed hypothyroidism in some. Expand