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Transdermal delivery of ketorolac tromethamine: permeation enhancement, device design, and pharmacokinetics in healthy humans.
  • S. Roy, E. Manoukian
  • Engineering, Chemistry
    Journal of pharmaceutical sciences
  • 1 October 1995
Transdermal delivery of ketorolac tromethamine, a potent non-narcotic analgesic, through human skin in vitro and in vivo was investigated and the permeability of ket orolac through various membranes such as a microporous membrane and pressure-sensitive adhesive was evaluated.
Permeability of ketorolac acid and its ester analogs (prodrug) through human cadaver skin.
KDAE appeared to be a better ester prodrug than KEE because it exhibited relatively higher skin flux and faster enzymatic hydrolysis by human serum to liberate the parent drug.
Absorption of transdermally delivered ketorolac acid in humans.
An excellent correlation between the in vitro steady-state skin flux and the area under the curve of in vivo plasma drug concentration versus time was observed for all the three formulations studied.
Glycolysis in dog skeletal muscle.
Permeability of pure enantiomers of ketorolac through human cadaver skin.
An excellent agreement between the predicted and experimental flux ratio of the racemic compound and enantiomers in the EVA membrane and cadaver skin was observed and the IPA/water/IPM (50:50:1.5) provided the highest in vitro skin flux of the S enantiomer among the three vehicle formulations studied.
Micellar Solubilization of Timobesone Acetate in Aqueous and Aqueous Propylene Glycol Solutions of Nonionic Surfactants
The micellar solubilization of timobesone acetate, a novel topical corticosteroid, was studied in aqueously and aqueous propylene glycol solutions of 1 to 5% nonionic surfactants at 25°C and the results support the equilibrium distribution model of micellars solubility.
The enzymatic microestimation of inosine, adenosine and inosinic acid.
Release of Lonapalene from Two-Phase Emulsion-Type Ointment Systems
The in vitro release of lonapalene, a novel nonsteroidal antipsoriatic agent, was studied from two-phase emulsion-type ointment systems into a perfect sink of propylene carbonate at 32°C to investigate the effects of the initial concentration, saturation level, and volume fraction of the internal phase.
The Enzymatic Microestimation of Urea
This enzymatic method permits the estimation of urea in as little as one microliter of serum and avoids the disadvantages inherent in color reactions such as nesslerization etc.