Release of Lonapalene from Two-Phase Emulsion-Type Ointment Systems

@article{Ong2004ReleaseOL,
  title={Release of Lonapalene from Two-Phase Emulsion-Type Ointment Systems},
  author={J. T. Ong and E. Manoukian},
  journal={Pharmaceutical Research},
  year={2004},
  volume={5},
  pages={16-20}
}
The in vitro release of lonapalene, a novel nonsteroidal antipsoriatic agent, was studied from two-phase emulsion-type ointment systems into a perfect sink of propylene carbonate at 32°C. Lonapalene was completely solubilized in the ointments consisting of an internal phase of propylene carbonate (PC)–propylene glycol (PG) mixture dispersed within an external phase of a petrolatum base. The PC:PG ratio was varied to investigate separately the effects of (1) the initial concentration of… Expand
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References

SHOWING 1-10 OF 11 REFERENCES
Release of corticoids from oleaginous ointment bases containing drug in suspension.
  • 38
Vehicle design for a new topical steroid, fluocinonide.
  • 71
Analysis of data on the medicament release from ointments.
  • W. Higuchi
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • 1962
  • 554
Topical nonsteroidal antipsoriatic agents. 1. 1,2,3,4-Tetraoxygenated naphthalene derivatives.
  • 26
...
1
2
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