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lixivaptan

Known as: 5-fluoro-2-methyl-N-(4-(5H-pyrrolo(2,1-c)-(1,4)benzodiazepin-10-(11H)-ylcarbonyl)-3-chlorophenyl)benzamide, WAY VPA-985, N-4-(3-chloro-4-(5H-pyrrolo(2,1-C)(1,4)benzodiazepin-10(11H)-ylcarbonyl)phenyl)-5-fluoro-2-methylbenzamide 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

BenzamidesPyrroles

Narrower (1)

VPA 985

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Evaluation of lixivaptan in euvolemic and hypervolemic hyponatremia and heart failure treatment
Introduction: Lixivaptan is a selective vasopressin type 2 (V2) receptor antagonist that induces aquaresis, the electrolytes… 
2011
2011
Biogen Idec restructures, sharpens neurology focus
It seems odd for a company in good financial health to undertake a dramatic restructuring, but Biogen Idec of Weston… 
2010
2010
Rationale and Design of the Treatment of Hyponatremia Based on Lixivaptan in NYHA Class III/IV Cardiac Patient Evaluation (THE BALANCE) Study
Hyponatremia is a common electrolyte disorder in patients with heart failure (HF) associated with cognitive dysfunction and… 
Review
2010
Review
2010
[Vasopressin receptor antagonists: the vaptans].
Review
2009
Review
2009
Lixivaptan: a novel vasopressin receptor antagonist
Arginine vasopressin, also known as antidiuretic hormone, is a neuropeptide that functions in the maintenance of body water… 
Review
2008
Review
2008
Mechanisms, Risks, and New Treatment Options for Hyponatremia
Hyponatremia is the most common electrolyte abnormality in hospitalized patients and is associated with increased mortality… 
Review
2008
Review
2008
Vasopressin and vasopressin antagonists in heart failure and hyponatremia
Increased synthesis of arginine vasopressin (AVP) plays a critical role in fluid retention and hyponatremia in patients with… 
Review
2006
Review
2006
Vasopressin antagonists as aquaretic agents for the treatment of hyponatremia.
Review
2006
Review
2006
Hyponatremia and heart failure--treatment considerations.
Hyponatremia as it occurs in the heart failure patient is a multifactorial process. The presence of hyponatremia in the heart… 
2003
2003
Gateways to clinical trials. March 2003.
Gateways to clinical Trials is a guide to the most recent clinical trials in current literature and congresses. The data in the… 
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