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A second wave of potential SSRIs with high ease of synthetic accessibility were designed based on the reported selective… Expand This study characterized the influence of acute administration of diverse classes of antidepressant agent upon the spontaneous… Expand Abstract— The influence of two selective serotonin reuptake inhibitors (SSRIs), litoxetine and fluoxetine, has been studied on 5… Expand We performed an extensive pharmacological study of the 5-hydroxytryptamine (5-HT) transporter polypeptide cloned from human… Expand 1 A combined study of receptor binding in central neuronal cell membranes and functional responses in isolated segments of guinea… Expand 1. The effects of a range of doses of litoxetine (twice daily for 4 days), a novel specific serotonin re-uptake inhibitor, were… Expand 1. Litoxetine is a selective serotonin reuptake inhibitor with antidepressant activity in animal models and in depressed patients… Expand The selective 5HT uptake inhibitor, litoxetine (SL 81.0385), currently under development as an antidepressant was shown to have… Expand Compounds known to selectively inhibit the neuronal reuptake of serotonin are clinically effective antidepressants. However, in a… Expand The sodium-ion coupled transporters for 5-hydroxytryptamine (5HT), noradrenaline and dopamine function to reduce extracellular… Expand