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liarozole

An orally-active benzimidazole derivative with potential antineoplastic activity. As a retinoic acid metabolism blocking agent, liarozole inhibits… Expand
National Institutes of Health

Papers overview

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2010
2010
OBJECTIVE To study the influence of liarozole on leiomyoma cell proliferation and extracellular matrix (ECM) gene expression in… Expand
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2007
2007
BACKGROUND Liarozole, a retinoic acid metabolism blocking agent, has been granted orphan drug status for congenital ichthyosis by… Expand
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2004
2004
Continuous oral dosing with all-trans retinoic acid (RA) is associated with a progressive decrease in plasma drug concentrations… Expand
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2001
2001
BACKGROUND Palmoplantar pustular psoriasis (PPP) is a chronic, relapsing condition often recalcitrant to therapy. Synthetic… Expand
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1999
1999
1α,25-Dihydroxyvitamin D3[ 1,25-(OH)2D3] inhibits the proliferation of many cancer cells in culture, but not the aggressive human… Expand
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1998
1998
The imidazole derivative liarozole is a potent inhibitor of cytochrome P450-dependent 4-hydroxylation of endogenous all-trans… Expand
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Highly Cited
1998
Highly Cited
1998
We report on the isolation of a cytochrome P450 (CYP)-like retinoic acid (RA) 4-hydroxylase cDNA from T-47D human breast cancer… Expand
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1998
1998
OBJECTIVES To compare the efficacy of oral liarozole, the first retinoic acid metabolism-blocking agent (RAMBA) to be developed… Expand
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Review
1993
Review
1993
BACKGROUND Ketoconazole, an imidazole derivative, is an orally active antifungal agent. In high doses (400 mg three times a day… Expand
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1992
1992
Liarozole is an imidazole-containing compound that inhibits the cytochrome P-450-dependent metabolism of all-trans-retinoic acid… Expand
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