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liarozole

An orally-active benzimidazole derivative with potential antineoplastic activity. As a retinoic acid metabolism blocking agent, liarozole inhibits… 
National Institutes of Health

Related topics

Related topics

11 relations

Broader (5)

Androgen AntagonistsAntineoplastic Agents, HormonalDermatologic AgentsEnzyme Inhibitors
Liarozole HydrochlorideNCIt Antineoplastic Agent Terminologyliarozole fumarate

Narrower (3)

LiazalR 085246R 75251

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Expression of retinoid-regulated genes in lamellar ichthyosis vs. healthy control epidermis: changes after oral treatment with liarozole.
Lamellar ichthyosis is a keratinization disorder caused by TGM1, Ichthyin and several other gene mutations. A new treatment… 
2006
2006
Synthesis and CYP26A1 inhibitory activity of 1-[benzofuran-2-yl-(4-alkyl/aryl-phenyl)-methyl]-1H-triazoles.
2004
2004
Modulation of all-trans retinoic acid pharmacokinetics by liarozole
Continuous oral dosing with all-trans retinoic acid (RA) is associated with a progressive decrease in plasma drug concentrations… 
2000
2000
Treatment of psoriasis with oral liarozole: a dose‐ranging study
Background Liarozole is an inhibitor of the metabolism of all‐trans‐retinoic acid. Systemic administration increases tissue… 
Highly Cited
1999
Highly Cited
1999
Liarozole Acts Synergistically with 1α,25-Dihydroxyvitamin D3 to Inhibit Growth of DU 145 Human Prostate Cancer Cells by Blocking 24-Hydroxylase Activity.
1α,25-Dihydroxyvitamin D3[ 1,25-(OH)2D3] inhibits the proliferation of many cancer cells in culture, but not the aggressive human… 
Highly Cited
1998
Highly Cited
1998
The effects of oral liarozole on epidermal proliferation and differentiation in severe plaque psoriasis are comparable with those of acitretin
The imidazole derivative liarozole is a potent inhibitor of cytochrome P450‐dependent 4‐hydroxyla‐tion of endogenous all‐trans… 
1998
1998
Novel nonsteroidal inhibitor of cytochrome P45017α (17α‐hydroxylase/C17–20 lyase), YM116, decreased prostatic weights by reducing serum concentrations of testosterone and adrenal androgens in rats
The purpose of this study was to determine the effects of a nonsteroidal C17–20 lyase inhibitor, 2‐(1H‐imidazol‐4‐ylmethyl)‐9H… 
1996
1996
Enhancement of antiproliferative activity of 1α,25-dihydroxyvitamin D3 (analogs) by cytochrome P450 enzyme inhibitors is compound- and cell-type specific
1996
1996
Liarozole amplifies retinoid‐induced apoptosis in human prostate cancer cells
Beta-carotene, canthaxanthin and retinoic acid (RA) inhibited growth of human DU145 prostate cancer cells by 45, 56 and 18… 
1995
1995
Liarozole, an antitumor drug, modulates cytokeratin expression in the dunning AT‐6sq prostatic carcinoma through in situ accumulation of all‐trans‐retinoic acid
Liarozole showed antitumoral activity in the Dunning AT‐6sq, an androgen‐independent rat prostate carcinoma. To investigate its… 
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