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liarozole

An orally-active benzimidazole derivative with potential antineoplastic activity. As a retinoic acid metabolism blocking agent, liarozole inhibits… Expand
National Institutes of Health

Papers overview

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2007
2007
Background  Liarozole, a retinoic acid metabolism blocking agent, has been granted orphan drug status for congenital ichthyosis… Expand
Highly Cited
2001
Highly Cited
2001
Background Palmoplantar pustular psoriasis (PPP) is a chronic, relapsing condition often recalcitrant to therapy. Synthetic… Expand
Highly Cited
1999
Highly Cited
1999
1α,25-Dihydroxyvitamin D3[ 1,25-(OH)2D3] inhibits the proliferation of many cancer cells in culture, but not the aggressive human… Expand
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Review
1998
Review
1998
Although significant advances have been made in the treatment of some malignancies, the prognosis of patients with metastatic… Expand
1998
1998
The imidazole derivative liarozole is a potent inhibitor of cytochrome P450‐dependent 4‐hydroxyla‐tion of endogenous all‐trans… Expand
Highly Cited
1998
Highly Cited
1998
OBJECTIVES To compare the efficacy of oral liarozole, the first retinoic acid metabolism-blocking agent (RAMBA) to be developed… Expand
1995
1995
Liarozole has been reported to inhibit P450 enzymes responsible for the catabolism of retinoic acid. This suggests that it may… Expand
Review
1993
Review
1993
Background. Ketoconazole, an imidazole derivative, is an orally active antifungal agent. In high doses (400 mg three times a day… Expand
Highly Cited
1992
Highly Cited
1992
Liarozole is a new imidazole derivative with antitumoral properties. Effects of the compound alone and in combination with all… Expand
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Highly Cited
1992
Highly Cited
1992
Liarozole is an imidazole-containing compound that inhibits the cytochrome P-450-dependent metabolism of all-trans-retinoic acid… Expand