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liarozole
An orally-active benzimidazole derivative with potential antineoplastic activity. As a retinoic acid metabolism blocking agent, liarozole inhibits…
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National Institutes of Health
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Related topics
Related topics
11 relations
Broader (5)
Androgen Antagonists
Antineoplastic Agents, Hormonal
Dermatologic Agents
Enzyme Inhibitors
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Liarozole Hydrochloride
NCIt Antineoplastic Agent Terminology
liarozole fumarate
Narrower (3)
Liazal
R 085246
R 75251
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Signaling Pathways in Leiomyoma: Understanding Pathobiology and Implications for Therapy
Mostafa A Borahay
,
A. Al-Hendy
,
G. Kilic
,
D. Boehning
Molecular medicine
2015
Corpus ID: 38280381
Uterine leiomyomas are the most common tumors of the female genital tract, affecting 50% to 70% of females by the age of 50…
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Review
2006
Review
2006
Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases.
V. Njar
,
L. Gediya
,
+7 authors
J. Patel
Bioorganic & medicinal chemistry
2006
Corpus ID: 25555181
Highly Cited
2001
Highly Cited
2001
Oral liarozole in the treatment of palmoplantar pustular psoriasis: a randomized, double‐blind, placebo‐controlled study
M. Bhushan
,
A. Burden
,
K. Mcelhone
,
R. James
,
F. Vanhoutte
,
C. Griffiths
The British journal of dermatology
2001
Corpus ID: 1578648
Background Palmoplantar pustular psoriasis (PPP) is a chronic, relapsing condition often recalcitrant to therapy. Synthetic…
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Highly Cited
1999
Highly Cited
1999
Liarozole Acts Synergistically with 1α,25-Dihydroxyvitamin D3 to Inhibit Growth of DU 145 Human Prostate Cancer Cells by Blocking 24-Hydroxylase Activity.
L. Ly
,
Xiao-yan Zhao
,
L. Holloway
,
D. Feldman
Endocrinology
1999
Corpus ID: 207072917
1α,25-Dihydroxyvitamin D3[ 1,25-(OH)2D3] inhibits the proliferation of many cancer cells in culture, but not the aggressive human…
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Review
1998
Review
1998
The emerging role of retinoids and retinoic acid metabolism blocking agents in the treatment of cancer
W. Miller
Cancer
1998
Corpus ID: 30302716
Although significant advances have been made in the treatment of some malignancies, the prognosis of patients with metastatic…
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1998
1998
The effects of oral liarozole on epidermal proliferation and differentiation in severe plaque psoriasis are comparable with those of acitretin
Kuijpers
,
Van Pelt
,
+5 authors
Schalkwijk
The British journal of dermatology
1998
Corpus ID: 43020316
The imidazole derivative liarozole is a potent inhibitor of cytochrome P450‐dependent 4‐hydroxyla‐tion of endogenous all‐trans…
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1995
1995
Liarozole potentiates the cancer chemopreventive activity of and the up-regulation of gap junctional communication and connexin43 expression by retinoic acid and beta-carotene in 10T1/2 cells.
P. Acevedo
,
J. Bertram
Carcinogenesis
1995
Corpus ID: 41723816
Liarozole has been reported to inhibit P450 enzymes responsible for the catabolism of retinoic acid. This suggests that it may…
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Review
1993
Review
1993
Ketoconazole and liarozole in the treatment of advanced prostatic cancer
C. Mahler
,
J. Verhelst
,
L. Denis
Cancer
1993
Corpus ID: 25770910
Background. Ketoconazole, an imidazole derivative, is an orally active antifungal agent. In high doses (400 mg three times a day…
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Highly Cited
1992
Highly Cited
1992
Liarozole, an inhibitor of retinoic acid metabolism, exerts retinoid-mimetic effects in vivo.
J. V. Van Wauwe
,
G. Van Nyen
,
+5 authors
P. Janssen
The Journal of pharmacology and experimental…
1992
Corpus ID: 36737493
Liarozole is an imidazole-containing compound that inhibits the cytochrome P-450-dependent metabolism of all-trans-retinoic acid…
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Highly Cited
1992
Highly Cited
1992
Effects of liarozole, a new antitumoral compound, on retinoic acid-induced inhibition of cell growth and on retinoic acid metabolism in MCF-7 human breast cancer cells.
W. Wouters
,
J. van Dun
,
A. Dillen
,
M. Coene
,
W. Cools
,
R. De Coster
Cancer research
1992
Corpus ID: 7276768
Liarozole is a new imidazole derivative with antitumoral properties. Effects of the compound alone and in combination with all…
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