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lestaurtinib

Known as: 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocin-1-one, 2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-, (9S,10S,12R)- 
A drug being studied in the treatment of acute leukemias and some other types of cancer. It binds to a protein that is present on the surface of some… 
National Institutes of Health

Related topics

Related topics

7 relations

Narrower (2)

CEP-701KT-5555

Broader (1)

Carbazoles
DDR1 protein, humanNCIt Antineoplastic Agent TerminologyReceptor Tyrosine Kinase InhibitionVascular Endothelial Growth Factor Receptor 2, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Compositions and methods for treatment of vitiligo
Methods of treating vitiligo using JAK/STAT modulating compounds are provided herein. The JAK/STAT modulating compounds may be… 
2015
2015
Development of a New Approach for the Therapy of Prostate Cancer with SPOP Mutations
Advanced prostate cancer is treated with androgen deprivation, but most patients eventually progress and need new therapy… 
2014
2014
UK boosts discovery tools
119 The US Food and Drug Administration put a clinical hold on all trials of Sanofi’s fedratinib, a highly selective JAK2… 
2013
2013
FLT 3 Inhibitors for the Treatment of Acute Myeloid Leukemia
634. 42. Hexner EO, Serdikoff C, Jan M, et al. Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and… 
2013
2013
fit for intensive chemotherapy treatment for older patients with acute myeloid leukemia not considered A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line
2012
2012
Fluvastatin inhibits FLT 3 glycosylation in human and murine cells and prolongs survival of mice with FLT 3 / ITD leukemia
FLT3 is frequently mutated in acute myeloid leukemia (AML), but resistance has limited the benefit of tyrosine kinase inhibitors… 
2011
2011
JAK2 en el linfoma de Hodgkin: Impacto pronóstico de la regulación mediada por miR-135a y análisis in vitro de Lestaurtinib
El linfoma de Hodgkin es una neoplasia de celulas B caracterizada por la escasa presencia de celulas tumorales, celulas de… 
2010
2010
Phase I trial of lestaurtinib for children with refractory neuroblastoma (NB): A New Approach to Neuroblastoma Therapy (NANT) Consortium study.
Purpose TrkB acts as an oncogenic kinase in a subset of human neuroblastomas. Lestaurtinib, a multi-kinase inhibitor with potent… 
2009
2009
Lestaurtinib as a FLT3 inhibitor
Overexpression of the FLT-3 receptor is common in Acute Myeloid Leukaemia (AML) and mutations represent one of the commonest… 
2008
2008
Gateways to clinical trials. July-August 2008.
(-)-Epigallocatechin gallate, 501516, 89-12; Abatacept, Adalimumab, Adefovir dipivoxil, AG-701, Agatolimod sodium, Alefacept…