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leptomycin B

Known as: 2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-, elactocin 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (3)

Antibiotics, AntineoplasticAntifungal AgentsFatty Acids, Unsaturated

Narrower (2)

CI 940PD 114720

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
RNA-related nuclear functions of human Pat1b, the P-body mRNA decay factor
Analysis of the nuclear life of human Pat1b, a member of the Pat1 family of RNA-binding proteins that at steady state reside in… 
2011
2011
p53-dependent anticancer effects of leptomycin B on lung adenocarcinoma
PurposeLeptomycin B (LMB) and/or its derivatives are considered a novel class of cancer therapeutics through blocking chromosome… 
Highly Cited
2006
Highly Cited
2006
BCR-ABL nuclear entrapment kills human CML cells: ex vivo study on 35 patients with the combination of imatinib mesylate and leptomycin B.
The BCR-ABL oncoprotein of chronic myelogenous leukemia (CML) localizes to the cell cytoplasm, where it activates proliferative… 
Highly Cited
2004
Highly Cited
2004
Proteolytic degradation of the nuclear isoform of uracil-DNA glycosylase occurs during the S phase of the cell cycle.
2004
2004
Nuclear export signal in CDC25B.
Highly Cited
2003
Highly Cited
2003
Small ubiquitin-like modifier conjugation regulates nuclear export of TEL, a putative tumor suppressor
Posttranslational modification by small ubiquitin-like modifier (SUMO) conjugation regulates the subnuclear localization of… 
Highly Cited
2000
Highly Cited
2000
Cytoplasmic Sequestration of Rel Proteins by IκBα Requires CRM1-Dependent Nuclear Export
ABSTRACT Rel and IκB protein families form a complex cellular regulatory network. A major regulatory function of IκB proteins is… 
Highly Cited
2000
Highly Cited
2000
MDM2-dependent ubiquitination of nuclear and cytoplasmic P53
Wild-type p53 is stabilized and accumulates in the nucleus of DNA damaged cells. The effect of stabilizing p53 is to inhibit cell… 
Highly Cited
1992
Highly Cited
1992
A leptomycin B resistance gene of Schizosaccharomyces pombe encodes a protein similar to the mammalian P‐glycoproteins
Screening for leptomycin B (LMB)‐resistant transformants in a gene library constructed in Schizosaccharomyces pombe with the… 
Highly Cited
1991
Highly Cited
1991
Highly synchronous culture of fibroblasts from G2 block caused by staurosporine, a potent inhibitor of protein kinases.
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