leiodermatolide
National Institutes of Health
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This review highlights the various challenges overcome during our recent synthetic campaign towards (−)-leiodermatolide, a potent…
Two new analogues of the potent antitumor compound leiodermatolide, which we call leiodermatolides B and C, have been isolated…
The C(1)–C(13) fragment of the antimitotic marine macrolide leiodermatolide is prepared in seven steps via hydrogenative and…
Pancreatic cancer, the fourth leading cause of cancer death in the United States, has a negative prognosis because metastasis…
The macrocyclic core (35) of the marine natural product leiodermatolide (1) was synthesized from two key fragments, vinyl iodide…
Leiodermatolide is an antimitotic macrolide isolated from the marine sponge Leiodermatium sp. whose potentially novel tubulin…
The title compound strongly inhibits the cell proliferation of several cancer cell lines in vitro.
The synthesis of the 16-membered core structure of leiodermatolide 40 has been achieved in 26 linear steps starting from (R…
The synthesis of three key fragments of the novel 16-membered macrolide leiodermatolide is described. The stereotetrad-containing…