The marine natural product microsclerodermin A is a novel inhibitor of the nuclear factor kappa B and induces apoptosis in pancreatic cancer cells
- E. Guzmán, K. Maers, Jill C. Roberts, Hilaire V. Kemami-Wangun, D. Harmody, A. Wright
- BiologyInvestigational new drugs
- 1 February 2015
Treatment of AsPC-1 cells with microsclerodermin A resulted in an increase in IL-8 production without apparent induction of angiogenic factors and there is the possibility that inhibition of NFκB by micro sclerodermine A is mediated by the glycogen synthase kinase 3β pathway.
Molecular Epidemiology of the fsr Locus and of Gelatinase Production among Different Subsets of Enterococcus faecalis Isolates
- Jill C. Roberts, Kavindra V. Singh, P. Okhuysen, B. Murray
- Biology, MedicineJournal of Clinical Microbiology
- 1 May 2004
Findings indicate that neither the two-component regulatory locus fsr nor gelatinase is required for E. faecalis to cause infection, and whether fsr or gelatinase affects the severity of disease, as it does in animal models is addressed.
Selective Killing of Dormant Mycobacterium tuberculosis by Marine Natural Products
- Carolina Rodrigues Felix, Rashmi Gupta, K. Rohde
- BiologyAntimicrobial Agents and Chemotherapy
- 12 June 2017
Four antimycobacterial compounds from marine organisms with novel activity profiles which appear to target M. tuberculosis pathways that are conditionally essential for dormancy survival are identified and characterized.
Leiodermatolide, a potent antimitotic macrolide from the marine sponge Leiodermatium sp.
- I. Paterson, S. M. Dalby, A. Wright
- Chemistry, BiologyAngewandte Chemie
- 28 March 2011
The title compound strongly inhibits the cell proliferation of several cancer cell lines in vitro and has shown high anti-cancer activity in vitro.
Analogues of the Potent Antitumor Compound Leiodermatolide from a Deep-Water Sponge of the Genus Leiodermatium.
- A. Wright, Jill C. Roberts, E. Guzmán, T. Pitts, S. Pomponi, J. Reed
- Biology, ChemistryJournal of Natural Products
- 30 January 2017
Two new analogues of the potent antitumor compound leiodermatolide have been isolated from specimens of a deep-water sponge of the genus LeioderMatium collected off Florida, providing a simpler analogue for possible clinical development.
Plakinamine P, A Steroidal Alkaloid with Bactericidal Activity against Mycobacterium tuberculosis
- Carolina Rodrigues Felix, Jill C. Roberts, K. Rohde
- Biology, MedicineMarine Drugs
- 1 December 2019
Investigation of the anti-mycobacterial activity of a deep-water sponge of the genus Plakina revealed the presence of a new steroidal alkaloid of the plakinamine class, which was bactericidal against M. tuberculosis, and exhibited moderate activity against other mycob bacterial pathogens.
Antiplasmodial Compounds from Deep-Water Marine Invertebrates
- A. Wright, Jennifer E Collins, D. Chakrabarti
- BiologyMarine Drugs
- 25 March 2021
Early life cycle exposure to Nitenin was identified as crucial to parasite inhibition, suggesting nitenin may target the maturation of the parasite during the transition from ring to early trophozoite (6–18 HPI), a novel property among known antimalarials.
Bacterial growth in media mimicking the high salt and alkalinity of extreme kazakhstan environments results in production of antimicrobial compounds in soil actinomycetes isolated from these…
- Jill C. Roberts, L. Trenozhnikova, Azliyati Azizan
- 13 April 2013
Streptomyces historically produce the largest number of antibacterials and herein it is described isolation of antagonists from extremophiles using unusual culture media.
High-Throughput Screening of a Marine Compound Library Identifies Anti-Cryptosporidium Activity of Leiodolide A
- Rachel M. Bone Relat, Priscilla L. Winder, R. O’Connor
- BiologyMarine Drugs
- 30 March 2022
The unique structure of leiodolide A provides a valuable drug scaffold on which to develop new anti-Cryptosporidium compounds and supports the importance of screening natural product libraries for new chemical scaffolds.
Marine Microbiome as a Source of Antimalarials
- P. McCarthy, Bracken F Roberts, A. Carbonell, Jill C. Roberts, A. Wright, D. Chakrabarti
- BiologyTropical Medicine and Infectious Disease
- 13 July 2019
The results establish that the marine microbiome is a rich source of antiplasmodial compounds that warrants in depth exploration.