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CyLoP-1: a novel cysteine-rich cell-penetrating peptide for cytosolic delivery of cargoes.
A novel, cationic cysteine-rich CPP, CyLoP-1, has been developed exhibiting distinguished diffused cytosol distribution along with endosomal uptake at low micromolar concentrations and might prove to be useful for efficient transmembrane delivery of agents directed to cytosolic targets.
Activity of Plasma Membrane V-ATPases Is Critical for the Invasion of MDA-MB231 Breast Cancer Cells*
- Kristina Cotter, Joseph Capecci, M. Forgac
- BiologyThe Journal of Biological Chemistry
- 10 December 2014
The results demonstrate that the anti-V5 antibody inhibits activity of plasma membrane V-ATPases in transfected cells, suggesting that plasma membranes V- ATPases play an important role in invasion of breast cancer cells.
The mechanism of gold(I)-catalyzed hydroalkoxylation of alkynes: an extensive experimental study.
It is shown that gold-catalyzed hydroalkoxylation of internal alkynes is a reaction that requires only one gold atom for the catalytic cycle, disproving a recent hypothesis regarding the involvement of cooperative gold catalysis.
Synthesis and characterization of new esters of oleic acid and glycerol analogues as potential lubricants
A formal total synthesis of the salicylihalamides.
The synthesis of the macrolactone 23 illustrates the conversion of a syn aldol product to the corresponding anti product by inversion of the methyl-bearing center.
Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone.
Synthesis of Pladienolide B and Its 7‐Epimer with Insights into the Role of the Allylic Acetate
Diastereomeric macrolactones 41 and 48, which are epimeric at C-7, were both prepared by a synthesis based on our previously developed route to the macrolactone core of pladienolide B. Both compounds…
Synthesis of a pladienolide B analogue with the fully functionalized core structure.
Starting from (R)-(-)-linalool (6), terminus differentiation and chain extension via aldol type reactions led to ketophosphonate 16 (C1-C8 building block). In a Horner-Wadsworth-Emmons reaction, 16…
Inhibition by Cellular Vacuolar ATPase Impairs Human Papillomavirus Uncoating and Infection
- Konstantin H Müller, Gilles A. Spoden, C. Muller
- Biology, ChemistryAntimicrobial Agents and Chemotherapy
- 10 March 2014
It is shown that V- ATPase is required for human papillomavirus (HPV) infection and that uncoating/disassembly but not endocytosis is affected by V-ATPase inhibition, indicating that broad-spectrum anti-HPV activity can be provided.