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CyLoP-1: a novel cysteine-rich cell-penetrating peptide for cytosolic delivery of cargoes.
TLDR
A novel, cationic cysteine-rich CPP, CyLoP-1, has been developed exhibiting distinguished diffused cytosol distribution along with endosomal uptake at low micromolar concentrations and might prove to be useful for efficient transmembrane delivery of agents directed to cytosolic targets.
Activity of Plasma Membrane V-ATPases Is Critical for the Invasion of MDA-MB231 Breast Cancer Cells*
TLDR
The results demonstrate that the anti-V5 antibody inhibits activity of plasma membrane V-ATPases in transfected cells, suggesting that plasma membranes V- ATPases play an important role in invasion of breast cancer cells.
The mechanism of gold(I)-catalyzed hydroalkoxylation of alkynes: an extensive experimental study.
TLDR
It is shown that gold-catalyzed hydroalkoxylation of internal alkynes is a reaction that requires only one gold atom for the catalytic cycle, disproving a recent hypothesis regarding the involvement of cooperative gold catalysis.
A formal total synthesis of the salicylihalamides.
  • C. Herb, M. Maier
  • Chemistry
    The Journal of organic chemistry
  • 23 September 2003
TLDR
The synthesis of the macrolactone 23 illustrates the conversion of a syn aldol product to the corresponding anti product by inversion of the methyl-bearing center.
Synthesis of Pladienolide B and Its 7‐Epimer with Insights into the Role of the Allylic Acetate
Diastereomeric macrolactones 41 and 48, which are epimeric at C-7, were both prepared by a synthesis based on our previously developed route to the macrolactone core of pladienolide B. Both compounds
Synthesis of a pladienolide B analogue with the fully functionalized core structure.
Starting from (R)-(-)-linalool (6), terminus differentiation and chain extension via aldol type reactions led to ketophosphonate 16 (C1-C8 building block). In a Horner-Wadsworth-Emmons reaction, 16
Inhibition by Cellular Vacuolar ATPase Impairs Human Papillomavirus Uncoating and Infection
TLDR
It is shown that V- ATPase is required for human papillomavirus (HPV) infection and that uncoating/disassembly but not endocytosis is affected by V-ATPase inhibition, indicating that broad-spectrum anti-HPV activity can be provided.
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