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Characterization of genetic markers for in vitro cell line identification of the marine sponge Axinella corrugata.
Molecular genetics methods and phylogeographic analyses of ITS DNA sequences helped clarify taxonomies and also suggested species boundaries between and among western Atlantic and eastern Atlantic/Indian Ocean A. corrugata and Axinellidae samples.
Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae.
Neopeltolide is a potent inhibitor of the in vitro proliferation of the A-549 human lung adenocarcinoma, the NCI-ADR-RES human ovarian sarcoma, and the P388 murine leukemia cell lines, with IC50's of 1.2, 5.1, and 0.56 nM, respectively.
Antitumor tetrahydroisoquinoline alkaloids from the colonial ascidian Ecteinascidia turbinata
- A. Wright, Dorilyn A. Forleo, G. Gunawardana, S. Gunasekera, F. Koehn, O. Mcconnell
- Chemistry, Biology
- 1 July 1990
A bioassay guided approach was used to isolate two antitumor tetrahydroisoquinoline alkaloids, 3 and 4, from the marine ascidian Ecteinascidia turbinata. The structures of 3 and 4 were determined…
The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells
- G. Kallifatidis, D. Hoepfner, Tiphaine Jaeg, E. Guzmán, A. Wright
- Biology, ChemistryMarine drugs
- 1 September 2013
Chemogenomic profiling in the yeast S. cerevisiae was performed, suggesting that manzamine A is an uncoupler of vacuolar ATPases, and a potential inhibitor of autophagy by preventing autophagosome turnover.
Discorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus Batzella.
A new discorhabdin analogue has been isolated from a deep-water marine sponge of the genus Batzella and inhibited the phosphat enzyme activity of calcineurin and the peptidase activity of CPP32 and showed in vitro cytotoxicity against P-388 and A-549 cell lines.
Structure elucidation of a new antifungal sterol sulfate, Sch 575867, from a deep-water marine sponge (Family: Astroscleridae).
It is described as a red-orange, rock hard, 15cm spherical sponge, with a thin veneer of living tissue over an aragonite skeleton, which is porous and smooth, with 2cm diameter mounds.
Interspecific differences in fouling of two congeneric ascidians (Eudistoma olivaceum and E. capsulatum): is surface acidity an effective defense?
Differences in the degree to which these congeneric ascidians are fouled is related to differences in the chemical defenses they possess, and Acidity is not an effective inhibitor of settlement by epifaunal invertebrates.
A systematic revision of the Central Atlantic Halichondrida (Demospongiae, Porifera). Part II. Patterns of distribution of secondary metabolites
Many morphological characters previously considered diagnostic at various taxonomic levels within the Halichondrida not only vary within taxa, but also occur in nonhalichondrid taxa.
Eryloside E from an atlantic sponge Erylus goffrilleri