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leadzyme

National Institutes of Health

Papers overview

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2009
2009
The dynamic nature of ribozymes represents a significant challenge in elucidating their structure-dynamics-function relationship… 
2005
2005
It is well known that Mg2+ and other divalent metal ions bind to the phosphate groups of nucleic acids. Subtle differences in the… 
2004
2004
Kinetic analysis of RNA enzymes, or ribozymes, typically involves the tedious process of collecting and quenching reaction time… 
Highly Cited
2003
Highly Cited
2003
The leadzyme is a small ribozyme, derived from in vitro selection, which catalyzes site specific, Pb(2+)-dependent RNA cleavage… 
1999
1999
The structure of a lead-dependent ribozyme reveals binding sites of divalent ions. One of them mimics the binding of catalytic… 
1998
1998
The Pb2+ cleavage of a specific phosphodiester bond in yeast tRNA(Phe) is the classical model of metal-assisted RNA catalysis. In… 
1997
1997
The structure/function properties of functional groups in the leadzyme have been studied by assaying the activity of analog… 
1997
1997
Leadzyme is a ribozyme that requires Pb2+. We have previously shown that the addition of Nd3+ in the presence of Pb2+ increased… 
1996
1996
SummaryA triple resonance HNC-TOCSY-CH experiment is described for correlating the guanosine imino proton and H8 resonances in…