leadzyme
National Institutes of Health
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The dynamic nature of ribozymes represents a significant challenge in elucidating their structure-dynamics-function relationship…
The leadzyme is a small ribozyme, derived from in vitro selection, which catalyzes site specific, Pb(2+)-dependent RNA cleavage…
This paper reports that the D-loop sequence of cellular mammalian ribosomal 5S RNAs is a natural leadzyme that specifically binds…
The leadzyme is a small RNA motif that catalyzes a site-specific, Pb 2+-dependent cleavage reaction. As such, it is an example of…
The structure of a lead-dependent ribozyme reveals binding sites of divalent ions. One of them mimics the binding of catalytic…
The Pb2+ cleavage of a specific phosphodiester bond in yeast tRNA(Phe) is the classical model of metal-assisted RNA catalysis. In…
The structure/function properties of functional groups in the leadzyme have been studied by assaying the activity of analog…
Leadzyme is a ribozyme that requires Pb2+. We have previously shown that the addition of Nd3+ in the presence of Pb2+ increased…
SummaryA triple resonance HNC-TOCSY-CH experiment is described for correlating the guanosine imino proton and H8 resonances in…