leadzyme
National Institutes of Health
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The dynamic nature of ribozymes represents a significant challenge in elucidating their structure-dynamics-function relationship…
It is well known that Mg2+ and other divalent metal ions bind to the phosphate groups of nucleic acids. Subtle differences in the…
Kinetic analysis of RNA enzymes, or ribozymes, typically involves the tedious process of collecting and quenching reaction time…
The leadzyme is a small ribozyme, derived from in vitro selection, which catalyzes site specific, Pb(2+)-dependent RNA cleavage…
The structure of a lead-dependent ribozyme reveals binding sites of divalent ions. One of them mimics the binding of catalytic…
The Pb2+ cleavage of a specific phosphodiester bond in yeast tRNA(Phe) is the classical model of metal-assisted RNA catalysis. In…
The structure/function properties of functional groups in the leadzyme have been studied by assaying the activity of analog…
Leadzyme is a ribozyme that requires Pb2+. We have previously shown that the addition of Nd3+ in the presence of Pb2+ increased…
SummaryA triple resonance HNC-TOCSY-CH experiment is described for correlating the guanosine imino proton and H8 resonances in…