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Catalytic RNA

Known as: Ribozyme, Ribozymes, RNA, Catalytic [Chemical/Ingredient] 
RNA that contains an intron sequence which has an enzyme-like catalytic activity. This intron sequence has been shown to fold up to form a complex… 
National Institutes of Health

Related topics

Related topics

25 relations

Narrower (14)

7-deaza-R34AngiozymeDiels-Alder ribozymeR3C ligase
Clinical Data Interchange Standards Consortium TerminologyEnzymesIn BloodProcess of secretion

Broader (1)

RNA

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Transforming growth factor-beta as a treatment target in renal diseases.
A number of studies have identified transforming growth factor-beta (TGF-beta) as a critical factor in renal diseases such as… 
2009
2009
Exploring Metal Ion Coordination to Nucleic Acids by NMR
Metal ions play a crucial role in charge compensation, folding and stabilization of tertiary structures of large nucleic acids… 
2006
2006
Potential for alternative intron-exon pairings in group II intron RmInt1 from Sinorhizobium meliloti and its relatives.
Ribozyme constructs derived from group II intron RmInt1 of Sinorhizobium meliloti self-splice in vitro when incubated under… 
Review
2005
Review
2005
Unnatural Protein Engineering: Producing Proteins with Unnatural Amino Acids
Less than a decade ago, the ability to generate proteins with unnatural modifications was a Herculean task available only to… 
2003
2003
Solvent protection of the hammerhead ribozyme in the ground state: evidence for a cation-assisted conformational change leading to catalysis.
Tertiary folding of the hammerhead ribozyme has been analyzed by hydroxyl radical footprinting. Three hammerhead constructs with… 
Review
2002
Review
2002
The power of ribozyme technologies: the logical way ahead for molecular medicine and gene therapy?
Since the discovery of naturally occurring non-protein enzymes called ribozymes, which cleave RNAs with high specificity akin to… 
2001
2001
A conformational change in the "loop E-like" motif of the hairpin ribozyme is coincidental with domain docking and is essential for catalysis.
The catalysis of site-specific RNA cleavage and ligation by the hairpin ribozyme requires the formation of a tertiary interaction… 
2001
2001
The human papillomavirus (HPV) 16 E6 oncoprotein leads to an increase in gene expression of the angiogenic switch molecule FGF-BP in non-immortalized human keratinocytes
Fibroblast growth factor binding protein (FGF-BP) is a secreted protein that binds FGF-1 and FGF-2 and is involved in… 
Highly Cited
2000
Highly Cited
2000
The 5'-end of hTERT mRNA is a good target for hammerhead ribozyme to suppress telomerase activity.
Because the expression level of hTERT, a catalytic subunit of human telomerase, is a rate-limiting determinant of telomerase… 
2000
2000
Solid-State 25 Mg NMR of a Magnesium(II) Adensosine 5'-Triphosphate Complex
The many significant roles that adenosine 5 ′-triphosphate (ATP) plays in chemical energy storage and transfer make this molecule…