landomycin E
National Institutes of Health
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We report here a transposon-based strategy to generate Streptomyces globisporus 1912 mutants with improved landomycin E…
Aim. To study the molecular mechanisms of action of novel anticancer antibiotic landomycin E (LE). Methods. Annexin V/propidium…
Eight highly productive UV-induced mutants of Streptomyces globisporus 1912 with high biosynthesis of landomycin E were isolated…
The screening of the positive regulators of landomycin E biosynthesis has been conducted among exogenous metabolites of the…
In Streptomyces cyanogenus S136 gene cluster for biosynthesis of polyglycosylated angucycline landomycin A (LaA), a divergently…
The prx gene, which is highly homologous to putative proteinases, has been identified by sequencing in the vicinity of the…
landomycinEbiosynthesis inStreptomycesglobisporus1912 Lilia Dutko, Yuriy Rebets, Bohdan Ostash, Andriy Luzhetskyy, Andreas…
Landomycin E (LE) was recently isolated from Streptomyces globisporus strain 1912 and its chemical structure was studied. However…
Streptomyces globisporus 1912 produces a novel angucycline antitumor antibiotic landomycin E (LE). To study the LE biosynthetic…