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Expression of Smad proteins in human colorectal cancer
The data show selective up‐regulation of receptor‐activated Smad proteins in human colorectal cancers and suggest involvement of Smad4 in differentiation and apoptosis of surface epithelial cells of normal crypts. Expand
A decisive role of mitochondria in defining rate and intensity of apoptosis induction by different alkaloids.
It is demonstrated that rapid cytochrome c release in CEM T-leukemia cells exposed to sanguinarine or chelerythrine was not accompanied by changes in Bax, Bcl-2 and BCl-X((L/S)) proteins in the mitochondrial fraction, and preceded activation of the initiator caspase-8. Expand
Differential effect of sanguinarine, chelerythrine and chelidonine on DNA damage and cell viability in primary mouse spleen cells and mouse leukemic cells
The cytotoxic and DNA damaging effects of chelerythrine and sanguinarine are more selective against mouse leukemic cells and primary mouse spleen cells, whereas chelidonine blocks proliferation of L1210 cells. Expand
Apoptogenic activity of two benzophenanthridine alkaloids from Chelidonium majus L. does not correlate with their DNA damaging effects.
It was shown earlier, that CHE, in contrast to SAN, does not interact directly with DNA, which is in line with DNA damaging effects of the alkaloids detected in the COMET assay, Nevertheless, apoptosis-inducing activity of CHE even slightly exceeded that of SAN. Expand
Lectinocytochemical detection of apoptotic murine leukemia L1210 cells
  • R. Bilyy, R. Stoika
  • Biology, Medicine
  • Cytometry. Part A : the journal of the…
  • 1 December 2003
This work investigated whether specific changes in the expression of plasma membrane glycoproteins take place during apoptosis and whether these changes could be used for a quantitative estimation of apoptosis. Expand
Giant cell formation: the way to cell death or cell survival?
Principal events that are observed during giant cell formation are described and the role of giant cells in cancer development is considered, taking into account both published work and their own recent data. Expand
Evaluation of biotargeting and ecotoxicity of Co²⁺-containing nanoscale polymeric complex by applying multi-marker approach in bivalve mollusk Anodonta cygnea.
Co(2+) complexing with the developed PS prevented bio-toxic effects of free Co( 2+) ions and PS per se, at least in the studied hydrobiont. Expand
Cytochemical study of role of alpha-d-mannose- and beta-d-galactose-containing glycoproteins in apoptosis.
It was demonstrated that an elevated expression of plasma membrane glycoproteins rich in alpha-d-mannose and beta- d-galactose did not depend on type of cell line and its tissue origin as well as on nature of apoptosis-inducing agent. Expand
Effect of anticancer drugs on production of transforming growth factor and expression of p53 AND Bcl-2 proteins by MCF-7 and T47D cell lines of human breast carcinoma.
In cells of human mammary carcinoma of MCF-7 and T47D lines doxorubicine, unlike vincristine and methotrexate, in dose depending manner induces production of TGF-beta(1), and there was no difference between these cell lines in sensitivity to other anticancer drugs. Expand
Macrophages Discriminate Glycosylation Patterns of Apoptotic Cell-derived Microparticles*
It is demonstrated that apoptotic cells release distinct types of subcellular membranous particles (scMP) derived from the endoplasmic reticulum (ER) or the plasma membrane, which may provide new insights into clearance-related diseases. Expand