FAQ

keratinocyte differentiation

Known as: keratinocyte cell differentiation 
The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte. [GOC:dph, GOC:mah, GOC:sdb_2009, GOC:tb]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1973-2018
05019732018

Related topics

Related topics

31 relations
CSTA geneCSTA wt AlleleCystatin-A, humanDermis
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Narrower (2)

Keratinization, functionkeratinocyte development

Broader (1)

skin development

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
keratinocyte differentiation
keratinocyte
Dermis
Histogenic Process
Intercellular Communication Process
Keratinization, function

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways.
BACKGROUND Psoriasis vulgaris is an inflammatory skin disease mediated by Th1 and Th17 cytokines, yet the relative contribution… (More)
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Highly Cited
2008
Highly Cited
2008
Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes.
Chronic inflammatory diseases are characterized by local tissue injury caused by immunocompetent cells, in particular CD4(+) T… (More)
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Highly Cited
2006
Highly Cited
2006
IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis.
IL-22 is an IFN-IL-10 cytokine family member, which is produced by activated Th1 and NK cells and acts primarily on epithelial… (More)
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Highly Cited
2005
Highly Cited
2005
IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes.
IL-22 belongs to a family of cytokines structurally related to IL-10, including IL-19, IL-20, IL-24, and IL-26. In contrast to IL… (More)
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Highly Cited
2005
Highly Cited
2005
Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control.
The Notch and Calcineurin/NFAT pathways have both been implicated in control of keratinocyte differentiation. Induction of the… (More)
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Highly Cited
2004
Highly Cited
2004
Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway.
The small Maf proteins, MafF, MafG, and MafK, possess a leucine zipper (Zip) domain that is required for homodimer or heterodimer… (More)
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Highly Cited
2001
Highly Cited
2001
Critical roles of PPAR beta/delta in keratinocyte response to inflammation.
The immediate response to skin injury is the release of inflammatory signals. It is shown here, by use of cultures of primary… (More)
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Highly Cited
2000
Highly Cited
2000
MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis
The matrix metalloproteinase MMP-9/gelatinase B is upregulated in angiogenic dysplasias and invasive cancers of the epidermis in… (More)
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Highly Cited
1997
Highly Cited
1997
The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2.
The high risk human papillomaviruses (HPVs) are associated etiologically with the majority of human cervical carcinomas. These… (More)
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Highly Cited
1992
Highly Cited
1992
Biosynthesis of human papillomavirus from a continuous cell line upon epithelial differentiation.
The study of the human pathogen papillomaviruses (HPVs) has been hampered by the inability to propagate the virus in tissue… (More)
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