High mobility group box 1 protein is released by neural cells upon different stresses and worsens ischemic neurodegeneration in vitro and in vivo
- G. Faraco, S. Fossati, A. Chiarugi
- BiologyJournal of Neurochemistry
- 1 October 2007
Investigation of the expression levels and relocation dynamics of HMGB1 in neural cells, as well as its neuropathological potential, point to the protein as a mediator of post‐ischemic brain damage.
Stimulated astrocytes release high-mobility group 1 protein, an inducer of LAN-5 neuroblastoma cell differentiation
- M. Passalacqua, M. Patrone, S. Pontremoli
- BiologyNeuroscience
- 12 November 1997
Introduction of the beta isozyme of protein kinase C accelerates induced differentiation of murine erythroleukemia cells.
- E. Melloni, S. Pontremoli, R. Rifkind
- BiologyProceedings of the National Academy of Sciences…
- 1 June 1990
Direct evidence for a rate-limiting role for this PKC isozyme during N,N'-hexamethylenebisacetamide-mediated induced differentiation of a transformed cell is provided.
3 – Selective Pro-Inflammatory Activation of Astrocytes by High Mobility Group Box 1 Protein Signaling
- M. Pedrazzi, E. Melloni, B. Sparatore
- Biology
- 2010
Binding of protein kinase C to neutrophil membranes in the presence of Ca2+ and its activation by a Ca2+-requiring proteinase.
- E. Melloni, S. Pontremoli, B. Horecker
- Biology, Computer ScienceProceedings of the National Academy of Sciences…
- 1 October 1985
In the presence of micromolar concentrations of Ca2+, both protein kinase C and a cytosolic Ca2+-requiring neutral proteinase of human neutrophils become associated with the neutrophil membrane and may have access, in the intact cell, to intracellular protein substrates.
Cutting Edge: Extracellular High Mobility Group Box-1 Protein Is a Proangiogenic Cytokine1
- S. Mitola, M. Belleri, M. Presta
- BiologyJournal of Immunology
- 1 January 2006
HMGB1 exerts proangiogenic effects by inducing MAPK ERK1/2 activation, cell proliferation, and chemotaxis in endothelial cells of different origin by inhibits HMGB1-induced neovascularization in vivo and endothelial cell proliferation and membrane ruffling in vitro.
Cytosolic Ca2+-dependent neutral proteinases from rabbit liver: activation of the proenzymes by Ca2+ and substrate.
- S. Pontremoli, E. Melloni, F. Salamino, B. Sparatore, M. Michetti, B. Horecker
- BiologyProceedings of the National Academy of Sciences…
- 1984
Two neutral Ca2+-dependent proteinases, differing in molecular size, have been isolated from rabbit liver. Both are recovered as inactive proenzymes that can be converted to the active forms by high…
Stimulation of excitatory amino acid release from adult mouse brain glia subcellular particles by high mobility group box 1 protein
- M. Pedrazzi, L. Raiteri, B. Sparatore
- Biology, ChemistryJournal of Neurochemistry
- 1 November 2006
The results suggest that the HMGB1 cytokine could act as a modulator of glutamate homeostasis in adult mammal brain.
The calpain-calpastatin system in mammalian cells: properties and possible functions.
- E. Melloni, F. Salamino, B. Sparatore
- Biology, ChemistryBiochimie
- 1 March 1992
A dual role for the Ca2+-requiring proteinase in the degradation of hemoglobin by erythrocyte membrane proteinases.
- S. Pontremoli, E. Melloni, B. Sparatore, M. Michetti, B. Horecker
- Biology, MedicineProceedings of the National Academy of Sciences…
- 1 November 1984
Regulation of the activity of the Ca2+-requiring proteinase by the substrate provides a mechanism for the initiation of selective protein turnover.
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