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interleukin-4 receptor activity

Known as: IL-4 receptor activity, IL-4R 
Combining with interleukin-4 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl… 
National Institutes of Health

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Interleukin 4 Receptor

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interleukin-4 binding activity

Papers overview

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2012
2012
Polymorphisms in the IL-13 and IL-4R genes are associated with the development of renal cell carcinoma.
BACKGROUND Cytokines are the important modulators that bind to their relevant receptors in response to some stimuli to mediate… 
2006
2006
IL-4R signaling is required to induce IL-10 for the establishment of T(h)2 dominance.
The requirement for IL-4 to promote differentiation of naive CD4(+) T cells into T(h)2 effector cell populations was established… 
Review
1999
Review
1999
Sharing of receptor subunits and signal transduction pathway between the IL-4 and IL-13 receptor system.
In this review, we summarize the subunit structure of the interleukin (IL)-4 and IL-13 receptor system and the molecular… 
Review
1998
Review
1998
Structure of and signal transduction through interleukin-4 and interleukin-13 receptors (review).
We have recently demonstrated that two different forms of IL-4R exist; classical or alternative. The classical IL-4R is… 
Highly Cited
1998
Highly Cited
1998
Interleukin 4 inhibits growth and induces apoptosis in human breast cancer cells.
Interleukin-4 (IL-4) is a pleiotropic cytokine produced by mast cells and T lymphocytes that promotes proliferation and… 
Highly Cited
1997
Highly Cited
1997
Interleukin-4 receptor blockade prevents airway responses induced by antigen challenge in mice.
The functional role of interleukin (IL)-4 in the development of airway hyperresponsiveness (AHR) and pulmonary eosinophilia in… 
Highly Cited
1995
Highly Cited
1995
Receptors for Interleukin (IL)-4 Do Not Associate with the Common γChain, and IL-4 Induces the Phosphorylation of JAK2 Tyrosine Kinase in Human Colon Carcinoma Cells (*)
We have previously reported on the expression of interleukin-4 receptors (IL-4R) on many human epithelial cancer cells; however… 
1994
1994
IL-4 induces chemotaxis of blood eosinophils from atopic dermatitis patients, but not from normal individuals.
T lymphocytes present in allergically inflamed tissue synthesize and secrete the cytokines interleukin (IL)-3, IL-4, IL-5, and… 
Highly Cited
1993
Highly Cited
1993
Expression of high affinity interleukin-4 receptors on human renal cell carcinoma cells and inhibition of tumor cell growth in vitro by interleukin-4.
Previously, Puri et al. (Puri, R. K., M. Ogata, P. Leland, G. M. Feldman, D. Fitzgerald, and I. Pastan. 1991. Cancer Res. 51:3011… 
Highly Cited
1990
Highly Cited
1990
Cytokine receptors and B cell functions. I. Recombinant soluble receptors specifically inhibit IL-1- and IL-4-induced B cell activities in vitro.
IL-1 and IL-4 are important mediators of B cell growth and differentiation. The cell-surface receptors for these cytokines have… 
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