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interleukin-12 complex

Known as: interleukin-12 complex location, IL-12 complex, p40 
A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of… 
National Institutes of Health

Related topics

Related topics

13 relations
ARHGEF2 geneCDK5R1 wt AlleleEBNA1BP2 geneIL12A gene

Broader (2)

Extracellular SpaceProtein complex

Narrower (1)

IL12B protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Distinct Antigen Delivery Systems Induce Dendritic Cells’ Divergent Transcriptional Response: New Insights from a Comparative and Reproducible Computational Analysis
Vaccination is the most successful and cost-effective method to prevent infectious diseases. However, many vaccine antigens have… 
2016
2016
Chromatin Remodeler Recruitment during Macrophage Differentiation Facilitates Transcription Factor Binding to Enhancers in Mature Cells*♦
We show how enhancers of macrophage-specific genes are rendered accessible in differentiating macrophages to allow their… 
2016
2016
Trabid epigenetically drives expression of IL-12 and IL-23
The production of interleukin 12 (IL-12) and IL-23 in dendritic cells is strictly regulated via epigenetic silencing. This… 
2015
2015
TNFAIP3 and IL12B gene polymorphisms associated with psoriasis vulgaris in an Egyptian cohort
Psoriasis vulgaris is a common chronic inflammatory skin disease. Development of early onset psoriasis is, to some extent… 
2015
2015
Association of Common Genetic Polymorphisms with Melanoma Patient IL-12p40 Blood Levels, Risk, and Outcomes
Recent investigation has identified association of IL-12p40 blood levels with melanoma recurrence and patient survival. No… 
2011
2011
Disparity of innate immunity–related gene effects on asthma and allergy on Karelia
To cite this article: Zhang G, Candelaria P, Mäkelä JM, Khoo S‐K, Hayden MC, von Hertzen L, Laatikainen T, Vartiainen E… 
2011
2011
Functional polymorphism in IL12B promoter site is associated with ulcerative colitis.
Ulcerative colitis (UC) is one of the two subtypes of inflammatory bowel disease (IBD). UC is a complex genetic disease that… 
2006
2006
IL10 and IL12B polymorphisms each influence IL‐12p70 secretion by dendritic cells in response to LPS
Dendritic cells (DC) are the main producers of the cytokine IL‐12p70, through which they play a direct role in the development of… 
2004
2004
Associations of the IL12B promoter polymorphism in longitudinal data from asthmatic patients 7 to 42 years of age.
2004
2004
Lack of association of interleukin-12 p40 gene (IL12B) polymorphism with Behçet's disease in the Japanese population.
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