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ARHGEF2 gene

Known as: KIAA0651, ARHGEF2, Rho/Rac Guanine Nucleotide Exchange Factor (GEF) 2 Gene 
This gene is involved in the modulation of GTPase signaling.
National Institutes of Health

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ARHGEF2 wt Allele
Cell Proliferation Regulatory ProcessCytoskeletal ModelingNegative Regulation of Microtubule DepolymerizationPhospholipid Binding

Papers overview

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2018
2018
A de novo 1q22q23.1 Interstitial Microdeletion in a Girl with Intellectual Disability and Multiple Congenital Anomalies Including Congenital Heart Defect
Many studies have shown that molecular karyotyping is an effective diagnostic tool in individuals with developmental delay… 
2017
2017
Co-dependency between KRAS addiction and ARHGEF2 promotes an adaptive escape from MAPK pathway inhibition
ABSTRACT Oncogenic KRAS engages multiple effector pathways including the MAPK cascade to promote proliferation and survival of… 
2017
2017
Identification of biomarkers for childhood obesity based on expressional correlation and functional similarity
The aim of the current study was to identify potential biomarkers of childhood obesity, and investigate molecular mechanisms and… 
2016
2016
An oncogenic KRAS transcription program activates the RHOGEF ARHGEF2 to mediate transformed phenotypes in pancreatic cancer
Activating mutations of KRAS are nearly ubiquitous in pancreatic adenocarcinomas occurring in greater than 90% of cases. Cellular… 
2016
2016
Transient resistance to DNA damaging agents is associated with expression of microRNAs-135b and -196b in human leukemia cell lines.
The acquisition of resistance to anticancer drugs is widely viewed as a key obstacle to successful cancer therapy. However… 
2016
2016
Crystal structure of hGEF-H1 PH domain provides insight into incapability in phosphoinositide binding.
2016
2016
14-3-3zeta mediates the recruitment of ARHGEF2 onto ROR1 to facilitate Wnt5a-induced CLL proliferation/migration
Author(s): Zhang, Lijia | Advisor(s): Kipps, Tomas J | Abstract: Chronic lymphocytic leukemia (CLL) is one of the most common… 
2015
2015
Dexamethasone-induced cellular tension requires a SGK1-stimulated Sec5–GEF-H1 interaction
ABSTRACT Dexamethasone, a synthetic glucocorticoid, is often used to induce osteoblast commitment of mesenchymal stem cells (MSCs… 
2011
2011
Bench to Bedside and Back Again: Personalizing Treatment for Patients with GIST
Commentary on: [Andrey Frolov, Santiago Chahwan, Michael Ochs, Juan Pablo Arnoletti, Zhong-Zong Pan, Olga Favorova, Jonathan… 
Review
2008
Review
2008
ARHGEF2 (rho/rac guanine nucleotide exchange factor (GEF) 2)
Review on ARHGEF2 (rho/rac guanine nucleotide exchange factor (GEF) 2), with data on DNA, on the protein encoded, and where the… 
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