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Integrated Genomic Analyses of Ovarian Carcinoma
It is reported that high-grade serous ovarian cancer is characterized by TP53 mutations in almost all tumours (96%); low prevalence but statistically recurrent somatic mutations in nine further genes including NF1, BRCA1,BRCA2, RB1 and CDK12; 113 significant focal DNA copy number aberrations; and promoter methylation events involving 168 genes. Expand
A Grb2-associated docking protein in EGF- and insulin-receptor signalling
- M. Holgado-Madruga, D. Emlet, D. Moscatello, A. Godwin, A. Wong
- Biology, Medicine
- 8 February 1996
It is concluded that Gabl is a new protein in EGF and insulin receptor signalling which could integrate signals from different systems and enhances cell growth and results in transformation. Expand
Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab.
- S. Khambata-Ford, C. Garrett, +15 authors D. Mauro
- Journal of clinical oncology : official journal…
- 1 May 2007
Gene expression profiles showed that patients with tumors that express high levels of the EGFR ligands epiregulin and amphireGulin and patients with wild-type K-ras are more likely to have disease control on cetuximab treatment. Expand
Comprehensive Characterization of Cancer Driver Genes and Mutations
This study reports a PanCancer and PanSoftware analysis spanning 9,423 tumor exomes (comprising all 33 of The Cancer Genome Atlas projects) and using 26 computational tools to catalog driver genes and mutations, identifying 299 driver genes with implications regarding their anatomical sites and cancer/cell types. Expand
The Molecular Taxonomy of Primary Prostate Cancer
A comprehensive molecular analysis of 333 primary prostate carcinomas revealed a molecular taxonomy in which 74% of these tumors fell into one of seven subtypes defined by specific gene fusions (ERG, ETV1/4, and FLI1) or mutations (SPOP, FOXA1, and IDH1). Expand
Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.
- W. Linehan, P. Spellman, +225 authors R. Zuna
- The New England journal of medicine
- 14 January 2016
Type 1 and type 2 papillary renal-cell carcinomas were shown to be different types of renal cancer characterized by specific genetic alterations, with type 2 further classified into three individual subgroups on the basis of molecular differences associated with patient survival. Expand
Oncogenic Signaling Pathways in The Cancer Genome Atlas
This work charted the detailed landscape of pathway alterations in 33 cancer types, stratified into 64 subtypes, and identified patterns of co-occurrence and mutual exclusivity. Expand
Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer
It is demonstrated that common genetic variants affect TGCT risk and implicate KITLG and SPRY4 as genes involved in TGCT susceptibility. Expand
Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair.
In vivo, depletion of BRCC36 and BRCC45 by the small interfering RNAs resulted in increased sensitivity to ionizing radiation and defects in G2/M checkpoint, identifying BRCC as a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. Expand
Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation
Novel stemness indices for assessing the degree of oncogenic dedifferentiation are provided and it is found that the dedifferentiated oncogenic phenotype was generally most prominent in metastatic tumors. Expand