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Integrated Genomic Analyses of Ovarian Carcinoma
It is reported that high-grade serous ovarian cancer is characterized by TP53 mutations in almost all tumours (96%); low prevalence but statistically recurrent somatic mutations in nine further genes including NF1, BRCA1,BRCA2, RB1 and CDK12; 113 significant focal DNA copy number aberrations; and promoter methylation events involving 168 genes.
Comprehensive Characterization of Cancer Driver Genes and Mutations
A Grb2-associated docking protein in EGF- and insulin-receptor signalling
- M. Holgado-Madruga, D. Emlet, D. Moscatello, A. Godwin, A. Wong
- Biology, Computer ScienceNature
- 8 February 1996
It is concluded that Gabl is a new protein in EGF and insulin receptor signalling which could integrate signals from different systems and enhances cell growth and results in transformation.
Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab.
Gene expression profiles showed that patients with tumors that express high levels of the EGFR ligands epiregulin and amphireGulin and patients with wild-type K-ras are more likely to have disease control on cetuximab treatment.
Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation
Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.
Type 1 and type 2 papillary renal-cell carcinomas were shown to be different types of renal cancer characterized by specific genetic alterations, with type 2 further classified into three individual subgroups on the basis of molecular differences associated with patient survival.
The Molecular Taxonomy of Primary Prostate Cancer
Oncogenic Signaling Pathways in The Cancer Genome Atlas
Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair.
Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer
It is demonstrated that common genetic variants affect TGCT risk and implicate KITLG and SPRY4 as genes involved in TGCT susceptibility.