FAQ

interleukin-10 receptor activity

Known as: IL-10 receptor activity, IL-10R 
Combining with interleukin-10 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl… (More)
National Institutes of Health

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Topic mentions per year

2001-2017
0120012017

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interleukin-10 binding activity

Related mentions per year

Related mentions per year

1994-2017
1990200020102020
interleukin-10 receptor activity
interleukin-10 binding activity

Papers overview

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2017
2017
Type I interferon signaling restrains IL-10R+ colonic macrophages and dendritic cells and leads to more severe Salmonella colitis
Type I interferons (IFNα, IFNβ) are key regulators of innate and adaptive immunity, modulating the severity of both viral and… (More)
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2015
2015
Tr1 Cells, but Not Foxp3+ Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10-Dependent Mechanism.
The two best-characterized types of CD4(+) regulatory T cells (Tregs) are Foxp3(+) Tregs and Foxp3(-) type 1 regulatory (Tr1… (More)
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Highly Cited
2014
Highly Cited
2014
Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function.
Intact interleukin-10 receptor (IL-10R) signaling on effector and T regulatory (Treg) cells are each independently required to… (More)
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2013
2013
Evidence for non-neutralizing autoantibodies against IL-10 signalling components in patients with inflammatory bowel disease
Inflammatory bowel disease constitutes a heterogeneous group of conditions, whose aetiology is only partly understood. The… (More)
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Highly Cited
2012
Highly Cited
2012
Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy.
BACKGROUND & AIMS Homozygous loss of function mutations in interleukin-10 (IL10) and interleukin-10 receptors (IL10R) cause… (More)
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2012
2012
IL-10R Blockade during Chronic Schistosomiasis Mansoni Results in the Loss of B Cells from the Liver and the Development of Severe Pulmonary Disease
In schistosomiasis patients, parasite eggs trapped in hepatic sinusoids become foci for CD4+ T cell-orchestrated granulomatous… (More)
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2011
2011
Inhibitor of PI3Kγ ameliorates TNBS-induced colitis in mice by affecting the functional activity of CD4+CD25+FoxP3+ regulatory T cells.
BACKGROUND AND PURPOSE Phosphoinositide 3-kinase-γ (PI3Kγ) is implicated in many pathophysiological conditions, and recent… (More)
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2005
2005
B cells play a regulatory role in mice infected with the L3 of Brugia pahangi.
Mice infected with the L3 of the filarial nematode Brugia pahangi make a strong T(h)2 response characterized by elevated levels… (More)
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Highly Cited
2003
Highly Cited
2003
The relative contribution of IL-4 receptor signaling and IL-10 to susceptibility to Leishmania major.
The roles of IL-10 and IL-4 receptor signaling were evaluated in a murine model of Leishmania major infection. In previous… (More)
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Highly Cited
2001
Highly Cited
2001
Regulatory activity of autocrine IL-10 on dendritic cell functions.
IL-10 is a critical cytokine that blocks the maturation of dendritic cells (DCs), but the relevance of autocrine IL-10 on DC… (More)
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