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indoleamine 2,3-dioxygenase activity

Known as: IDO 
Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate; D-tryptophan produces N-formyl… 
National Institutes of Health

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2 relations
INDO wt AlleleIndoleamine 2,3-Dioxygenase, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Resveratrol suppresses tumor progression via the regulation of indoleamine 2,3-dioxygenase.
2012
2012
Human periodontal ligament cells facilitate leukocyte recruitment and are influenced in their immunomodulatory function by Th17 cytokine release.
2011
2011
Effects of PEG-interferon alpha plus ribavirin on tryptophan metabolism in patients with chronic hepatitis C.
2011
2011
Plasmacytoid dendritic cells in tolerance.
Dendritic cells (DC) are professional antigen-presenting cells (APCs) that modulate the outcome of the immune response toward… 
2010
2010
Human uterine epithelial cell secretions regulate dendritic cell differentiation and responses to TLR ligands
The balance between immunity and tolerance in the endometrium is governed by dynamic interactions of UEC and immune cells… 
2009
2009
Human Activated T Lymphocytes Modulate IDO Expression in Tumors through Th1/Th2 Balance1
Previous cancer vaccination approaches have shown some efficiency in generating measurable immune responses, but they have rarely… 
2007
2007
Anti-CD28 Antibodies Modify Regulatory Mechanisms and Reinforce Tolerance in CD40Ig-Treated Heart Allograft Recipients1
Blockade of CD40-CD40 ligand (CD40L) costimulation has been shown to synergize with that of CTLA4/CD28-B7 to promote transplant… 
Review
2005
Review
2005
Marrying immunotherapy with chemotherapy: why say IDO?
Activation of the tryptophan catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) in cancer cells facilitates immune escape. A… 
Review
1996
Review
1996
Utilization of superoxide anion by indoleamine oxygenase-catalyzed tryptophan and indoleamine oxidation.
The following is our current working hypothesis concerning the biological significance of IDO induction. When tissues are invaded… 
Highly Cited
1995
Highly Cited
1995
Upregulation of interferon-induced indoleamine 2,3-dioxygenase in human macrophage cultures by lipopolysaccharide, muramyl tripeptide, and interleukin-1.
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