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immucillin H

Known as: 1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-iminoribitol, Forodesine, ImmH cpd 
A substance being studied in the treatment of some types of leukemia and lymphoma. It is a type of purine nucleoside phosphorylase (PNP) inhibitor.
National Institutes of Health

Related topics

Related topics

4 relations

Narrower (1)

BCX1777

Broader (2)

Purine NucleosidesPyrimidinones
forodesine hydrochloride

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Adenosine A1 Receptor-Dependent Antinociception Induced by Inosine in Mice: Pharmacological, Genetic and Biochemical Aspects
Inosine is an endogenous nucleoside that has anti-inflammatory and antinociceptive properties. Inosine is a metabolite of… 
Review
2013
Review
2013
Older and new purine nucleoside analogs for patients with acute leukemias.
Highly Cited
2010
Highly Cited
2010
Influence of bone marrow stromal microenvironment on forodesine-induced responses in CLL primary cells.
Forodesine, a purine nucleoside phosphorylase inhibitor, displays in vitro activity in chronic lymphocytic leukemia (CLL) cells… 
Highly Cited
2009
Highly Cited
2009
Transition state analogues of 5′-methylthioadenosine nucleosidase disrupt quorum sensing
SUMMARY 5′-Methylthioadenosine nucleosidase (MTAN) is a bacterial enzyme involved in S-adenosylmethionine-related quorum sensing… 
Review
2006
Review
2006
Novel purine nucleoside analogues for T-cell-lineage acute lymphoblastic leukaemia and lymphoma
Purine nucleoside phosphorylase (PNP) deficiency is a rare, inherited immunodeficiency disorder in which the specific molecular… 
Highly Cited
2005
Highly Cited
2005
A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine).
The discovery of purine nucleoside phosphorylase (PNP) deficiency and T lymphocytopenia suggested that inhibition of this enzyme… 
Highly Cited
2003
Highly Cited
2003
Crystal structure of human purine nucleoside phosphorylase complexed with acyclovir.
Highly Cited
2001
Highly Cited
2001
Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes
Transition-state theory has led to the design of Immucillin-H (Imm-H), a picomolar inhibitor of purine nucleoside phosphorylase… 
2001
2001
Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces.
A structural genomics comparison of purine nucleoside phosphorylases (PNPs) indicated that the enzyme encoded by Mycobacterium… 
2000
2000
Immucillin‐H binding to purine nucleoside phosphorylase reduces dynamic solvent exchange
The rate and extent of hydrogen/deuterium (H/D) exchange into purine nucleoside phosphorylase (PNP) was monitored by electrospray… 
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