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immucillin H

Known as: 1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-iminoribitol, Forodesine, ImmH cpd 
A substance being studied in the treatment of some types of leukemia and lymphoma. It is a type of purine nucleoside phosphorylase (PNP) inhibitor.
National Institutes of Health

Related topics

Related topics

4 relations

Narrower (1)

BCX1777

Broader (2)

Purine NucleosidesPyrimidinones
forodesine hydrochloride

Papers overview

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Review
2013
Review
2013
Older and new purine nucleoside analogs for patients with acute leukemias.
Review
2012
Review
2012
Current and Emerging Treatment Strategies for Cutaneous T-cell Lymphoma
Cutaneous T-cell lymphomas (CTCLs) are a rare group of mature T-cell lymphomas presenting primarily in the skin. The most common… 
Highly Cited
2011
Highly Cited
2011
Plasmodium falciparum Parasites Are Killed by a Transition State Analogue of Purine Nucleoside Phosphorylase in a Primate Animal Model
Plasmodium falciparum causes most of the one million annual deaths from malaria. Drug resistance is widespread and novel agents… 
Review
2009
Review
2009
How I treat mycosis fungoides and Sézary syndrome.
The most common subtypes of primary cutaneous T-cell lymphomas are mycosis fungoides (MF) and Sézary syndrome (SS). The majority… 
Highly Cited
2009
Highly Cited
2009
Transition state analogues of 5′-methylthioadenosine nucleosidase disrupt quorum sensing
SUMMARY 5′-Methylthioadenosine nucleosidase (MTAN) is a bacterial enzyme involved in S-adenosylmethionine-related quorum sensing… 
Highly Cited
2009
Highly Cited
2009
Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 and BIM.
Chronic lymphocytic leukemia (CLL) is an incurable disease derived from the monoclonal expansion of CD5(+) B lymphocytes. High… 
Review
2008
Review
2008
Cytotoxic nucleoside analogues: different strategies to improve their clinical efficacy.
Cytotoxic nucleoside analogues are clinically important anticancer drugs. These agents behave as antimetabolites, compete with… 
Review
2008
Review
2008
Novel therapies for cutaneous T-cell lymphomas.
  • S. Horwitz
  • Clinical Lymphoma & Myeloma
  • 2008
  • Corpus ID: 21434337
Cutaneous T-cell lymphomas (CTCLs) are a group of uncommon mature T-cell lymphomas presenting primarily or exclusively in the… 
Highly Cited
2005
Highly Cited
2005
A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine).
The discovery of purine nucleoside phosphorylase (PNP) deficiency and T lymphocytopenia suggested that inhibition of this enzyme… 
Highly Cited
2001
Highly Cited
2001
Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes
Transition-state theory has led to the design of Immucillin-H (Imm-H), a picomolar inhibitor of purine nucleoside phosphorylase… 
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