FAQ

immucillin H

Known as: 1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-iminoribitol, Forodesine, ImmH cpd 
A substance being studied in the treatment of some types of leukemia and lymphoma. It is a type of purine nucleoside phosphorylase (PNP) inhibitor.
National Institutes of Health

Topic mentions per year

Topic mentions per year

2000-2018
051020002018

Related topics

Related topics

4 relations

Narrower (1)

BCX1777

Broader (2)

Purine NucleosidesPyrimidinones
forodesine hydrochloride

Related mentions per year

Related mentions per year

1945-2018
19401960198020002020
immucillin H
Purine Nucleosides
Pyrimidinones
BCX1777
forodesine hydrochloride

Papers overview

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2012
2012
Serum 25-dihydroxyvitamin D levels correlate with CD4(+)Foxp3(+) T-cell numbers in moderate/severe asthma.
impact of B-cell immunodeficiency in cases of PNP deficiency and is probably explained by the complete lack of PNP enzyme… (More)
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2009
2009
Third-generation immucillins: syntheses and bioactivities of acyclic immucillin inhibitors of human purine nucleoside phosphorylase.
ImmH (1) and DADMe-ImmH (2) are potent inhibitors of human purine nucleoside phoshorylase (PNP), developed by us and currently in… (More)
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2008
2008
Determinants of sensitivity of human T-cell leukemia CCRF-CEM cells to immucillin-H.
Immucillin-H (BCX-1777, forodesine) is a transition state analogue and potent inhibitor of PNP that shows promise as a specific… (More)
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2005
2005
A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine).
The discovery of purine nucleoside phosphorylase (PNP) deficiency and T lymphocytopenia suggested that inhibition of this enzyme… (More)
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2005
2005
Femtomolar transition state analogue inhibitors of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli.
Escherichia coli 5'-methylthioadenosine/S-adenosyl-homocysteine nucleosidase (MTAN) hydrolyzes its substrates to form adenine and… (More)
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2002
2002
Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase.
Plasmodium falciparum is responsible for the majority of life-threatening cases of malaria. Plasmodia species cannot synthesize… (More)
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2001
2001
Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes.
Transition-state theory has led to the design of Immucillin-H (Imm-H), a picomolar inhibitor of purine nucleoside phosphorylase… (More)
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2001
2001
Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces.
A structural genomics comparison of purine nucleoside phosphorylases (PNPs) indicated that the enzyme encoded by Mycobacterium… (More)
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2001
2001
Purine nucleoside phosphorylase inhibitor BCX-1777 (Immucillin-H)--a novel potent and orally active immunosuppressive agent.
Patients with purine nucleoside phosphorylase (PNP) deficiency present a selective T-cell immunodeficiency. Inhibitors of PNP are… (More)
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2000
2000
Immucillin-H binding to purine nucleoside phosphorylase reduces dynamic solvent exchange.
The rate and extent of hydrogen/deuterium (H/D) exchange into purine nucleoside phosphorylase (PNP) was monitored by electrospray… (More)
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