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immucillin H
Known as:
1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-iminoribitol
, Forodesine
, ImmH cpd
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A substance being studied in the treatment of some types of leukemia and lymphoma. It is a type of purine nucleoside phosphorylase (PNP) inhibitor.
National Institutes of Health
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Related topics
Related topics
4 relations
Narrower (1)
BCX1777
Broader (2)
Purine Nucleosides
Pyrimidinones
forodesine hydrochloride
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Older and new purine nucleoside analogs for patients with acute leukemias.
P. Robak
,
T. Robak
Cancer Treatment Reviews
2013
Corpus ID: 29722215
Review
2012
Review
2012
Current and Emerging Treatment Strategies for Cutaneous T-cell Lymphoma
F. Lansigan
,
F. Foss
Drugs
2012
Corpus ID: 46493517
Cutaneous T-cell lymphomas (CTCLs) are a rare group of mature T-cell lymphomas presenting primarily in the skin. The most common…
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Highly Cited
2011
Highly Cited
2011
Plasmodium falciparum Parasites Are Killed by a Transition State Analogue of Purine Nucleoside Phosphorylase in a Primate Animal Model
M. Cassera
,
Keith Z. Hazleton
,
+9 authors
V. Schramm
PLoS ONE
2011
Corpus ID: 1631506
Plasmodium falciparum causes most of the one million annual deaths from malaria. Drug resistance is widespread and novel agents…
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Review
2009
Review
2009
How I treat mycosis fungoides and Sézary syndrome.
H. Prince
,
S. Whittaker
,
R. Hoppe
Blood
2009
Corpus ID: 8812067
The most common subtypes of primary cutaneous T-cell lymphomas are mycosis fungoides (MF) and Sézary syndrome (SS). The majority…
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Highly Cited
2009
Highly Cited
2009
Transition state analogues of 5′-methylthioadenosine nucleosidase disrupt quorum sensing
Jemy A. Gutierrez
,
T. Crowder
,
A. Rinaldo-Matthis
,
M. Ho
,
S. Almo
,
V. Schramm
Nature Chemical Biology
2009
Corpus ID: 18314560
SUMMARY 5′-Methylthioadenosine nucleosidase (MTAN) is a bacterial enzyme involved in S-adenosylmethionine-related quorum sensing…
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Highly Cited
2009
Highly Cited
2009
Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 and BIM.
R. Alonso
,
M. López-Guerra
,
+9 authors
D. Colomer
Blood
2009
Corpus ID: 22800306
Chronic lymphocytic leukemia (CLL) is an incurable disease derived from the monoclonal expansion of CD5(+) B lymphocytes. High…
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Review
2008
Review
2008
Cytotoxic nucleoside analogues: different strategies to improve their clinical efficacy.
C. Galmarini
,
F. Popowycz
,
B. Joseph
Current Medicinal Chemistry
2008
Corpus ID: 10741137
Cytotoxic nucleoside analogues are clinically important anticancer drugs. These agents behave as antimetabolites, compete with…
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Review
2008
Review
2008
Novel therapies for cutaneous T-cell lymphomas.
S. Horwitz
Clinical Lymphoma & Myeloma
2008
Corpus ID: 21434337
Cutaneous T-cell lymphomas (CTCLs) are a group of uncommon mature T-cell lymphomas presenting primarily or exclusively in the…
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Highly Cited
2005
Highly Cited
2005
A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine).
V. Gandhi
,
J. Kilpatrick
,
+9 authors
D. Thomas
Blood
2005
Corpus ID: 278201
The discovery of purine nucleoside phosphorylase (PNP) deficiency and T lymphocytopenia suggested that inhibition of this enzyme…
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Highly Cited
2001
Highly Cited
2001
Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes
G. Kicska
,
Li Long
,
+5 authors
H. Kaufman
Proceedings of the National Academy of Sciences…
2001
Corpus ID: 22771420
Transition-state theory has led to the design of Immucillin-H (Imm-H), a picomolar inhibitor of purine nucleoside phosphorylase…
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